CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007460
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ETS translocation variant 1 
Protein Synonyms/Alias
 Ets-related protein 81 
Gene Name
 Etv1 
Gene Synonyms/Alias
 Er81; Etsrp81 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
33PTNVRKRKFINRDLAacetylation[1]
116FKFSYGEKCLYNVSAacetylation[1]
Reference
 [1] Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.
 Goel A, Janknecht R.
 Mol Cell Biol. 2003 Sep;23(17):6243-54. [PMID: 12917345] 
Functional Description
 Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. 
Sequence Annotation
 DNA_BIND 335 415 ETS.
 MOD_RES 191 191 Phosphoserine; by RPS6KA1 and RPS6KA5 (By
 MOD_RES 216 216 Phosphoserine; by RPS6KA1 and RPS6KA5 (By  
Keyword
 Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 477 AA 
Protein Sequence
MDGFYDQQVP YVVTNSQRGR NCTEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE 60
AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSELG SACSQEQPFK FSYGEKCLYN 120
VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNTAHTPK PDRAFPAHLP PSQSIPDSTY 180
PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHTT 240
MVGGAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ 300
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG 360
MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA 420
LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMTYM PEGGCCNPHP YNEGYVY 477 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:MGI.
 GO:0007411; P:axon guidance; IMP:MGI.
 GO:0007638; P:mechanosensory behavior; IMP:MGI.
 GO:0007517; P:muscle organ development; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000418; Ets_dom.
 IPR006715; ETS_PEA3_N.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00178; Ets
 PF04621; ETS_PEA3_N 
SMART
 SM00413; ETS 
PROSITE
 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 
PRINTS
 PR00454; ETSDOMAIN.