CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007715
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tail-specific protease 
Protein Synonyms/Alias
 C-terminal-processing peptidase; PRC protein; Protease Re 
Gene Name
 prc 
Gene Synonyms/Alias
 STM1845 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
182LSLKLTGKSDKEIREacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses (By similarity). 
Sequence Annotation
 DOMAIN 238 322 PDZ.
 ACT_SITE 452 452 Charge relay system (By similarity).
 ACT_SITE 463 463 Charge relay system (By similarity).
 ACT_SITE 477 477 Charge relay system (By similarity).  
Keyword
 Cell inner membrane; Cell membrane; Complete proteome; Hydrolase; Membrane; Protease; Reference proteome; Serine protease; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 682 AA 
Protein Sequence
MNTFFRLTAL AGLLALAGQS FAVEDITRAD QIPVLKEETQ HATVSERVTS RFTRSHYRQF 60
DLDEAFSAKI FDRYLNLLDY SHNVLLASDV EQFAKKKTVL GDELRTGKLD VFYDLYNLAQ 120
KRRFERYQYA LKVLERPMDF TGNDTFNLDR SKAPWPKDEA ELNALWDGKV KFDELSLKLT 180
GKSDKEIRET LTRRYKFAIR RLAQTNSEDV FSLAMTAFAR EIDPHTNYLS PRNTEQFNTE 240
MSLSLEGIGA VLQMDDDYTV INSLVAGGPA AKSKSISVGD RIVGVGQAGK PMVDVIGWRL 300
DDVVALIKGP KGSKVRLEIL PAGKGTKTRI ITLTRERIRL EDRAVKMSVK TVGKEKVGVL 360
DIPGFYVGLT DDVKVQLQKL EKQNVNSIVI DLRSNGGGAL TEAVSLSGLF IPSGPIVQVR 420
DNNGKVREDS DTDGVVYYKG PLVVLVDRFS ASASEIFAAA MQDYGRALIV GEPTFGKGTV 480
QQYRSLNRIY DQMLRPEWPA LGSVQYTIQK FYRVNGGSTQ RKGVTPDIIM PTGNEETETG 540
EKFEDNALPW DSIDAAKYVK SDDLAPFGPE LLKEHNARIA KDPEFQYIMK DIARFNAMKD 600
KRNIVSLNYA QREKENNEED ALRLARINDR FKREGKPLLK KLDDLPKDYQ EPDPYLDETV 660
KIALDLAHLE KEKPAEQAAA NK 682 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR005151; Interphotoreceptor_retinol-bd.
 IPR001478; PDZ.
 IPR004447; Peptidase_S41A.
 IPR020992; Tail_Prtase_C. 
Pfam
 PF11818; DUF3340
 PF00595; PDZ
 PF03572; Peptidase_S41 
SMART
 SM00228; PDZ
 SM00245; TSPc 
PROSITE
 PS50106; PDZ 
PRINTS