CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020353
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell adhesion molecule 1 
Protein Synonyms/Alias
 Immunoglobulin superfamily member 4; IgSF4; Nectin-like protein 2; NECL-2; Spermatogenic immunoglobulin superfamily; SgIgSF; Synaptic cell adhesion molecule; SynCAM; Tumor suppressor in lung cancer 1; TSLC-1 
Gene Name
 CADM1 
Gene Synonyms/Alias
 IGSF4; IGSF4A; NECL2; SYNCAM; TSLC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
412TYFTHEAKGADDAADubiquitination[1, 2]
437GQNNSEEKKEYFI**ubiquitination[1, 2]
438QNNSEEKKEYFI***ubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. 
Sequence Annotation
 DOMAIN 45 139 Ig-like V-type.
 DOMAIN 144 238 Ig-like C2-type 1.
 DOMAIN 243 329 Ig-like C2-type 2.
 MOD_RES 434 434 Phosphoserine (By similarity).
 CARBOHYD 67 67 N-linked (GlcNAc...) (Potential).
 CARBOHYD 101 101 N-linked (GlcNAc...).
 CARBOHYD 113 113 N-linked (GlcNAc...).
 CARBOHYD 165 165 N-linked (GlcNAc...) (Potential).
 CARBOHYD 301 301 N-linked (GlcNAc...); atypical.
 CARBOHYD 302 302 N-linked (GlcNAc...); atypical.
 CARBOHYD 304 304 N-linked (GlcNAc...) (Potential).
 CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
 DISULFID 64 124 By similarity.
 DISULFID 166 220 By similarity.
 DISULFID 267 313 By similarity.  
Keyword
 3D-structure; Alternative splicing; Apoptosis; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Spermatogenesis; Synapse; Transmembrane; Transmembrane helix; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MASVVLPSGS QCAAAAAAAA PPGLRLRLLL LLFSAAALIP TGDGQNLFTK DVTVIEGEVA 60
TISCQVNKSD DSVIQLLNPN RQTIYFRDFR PLKDSRFQLL NFSSSELKVS LTNVSISDEG 120
RYFCQLYTDP PQESYTTITV LVPPRNLMID IQKDTAVEGE EIEVNCTAMA SKPATTIRWF 180
KGNTELKGKS EVEEWSDMYT VTSQLMLKVH KEDDGVPVIC QVEHPAVTGN LQTQRYLEVQ 240
YKPQVHIQMT YPLQGLTREG DALELTCEAI GKPQPVMVTW VRVDDEMPQH AVLSGPNLFI 300
NNLNKTDNGT YRCEASNIVG KAHSDYMLYV YDPPTTIPPP TTTTTTTTTT TTTILTIITD 360
SRAGEEGSIR AVDHAVIGGV VAVVVFAMLC LLIILGRYFA RHKGTYFTHE AKGADDAADA 420
DTAIINAEGG QNNSEEKKEY FI 442 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
 GO:0005911; C:cell-cell junction; ISS:UniProtKB.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0030165; F:PDZ domain binding; ISS:UniProtKB.
 GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0005102; F:receptor binding; ISS:UniProtKB.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0016338; P:calcium-independent cell-cell adhesion; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0008037; P:cell recognition; IDA:UniProtKB.
 GO:0051606; P:detection of stimulus; IDA:UniProtKB.
 GO:0007157; P:heterophilic cell-cell adhesion; ISS:UniProtKB.
 GO:0007156; P:homophilic cell adhesion; ISS:UniProtKB.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0050715; P:positive regulation of cytokine secretion; IDA:UniProtKB.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
 GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IDA:UniProtKB.
 GO:0007416; P:synapse assembly; IEA:Compara.
 GO:0009826; P:unidimensional cell growth; IEA:Compara. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set.
 IPR003585; Neurexin-like. 
Pfam
 PF08205; C2-set_2
 PF07686; V-set 
SMART
 SM00294; 4.1m
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS