CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017920
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GA-binding protein subunit beta-2 
Protein Synonyms/Alias
 GABP subunit beta-2; GABPB-2 
Gene Name
 GABPB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MSLVDLGKRLLEAARubiquitination[1]
138HAFSKFDKSAFDIALubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity). 
Sequence Annotation
 REPEAT 5 34 ANK 1.
 REPEAT 37 66 ANK 2.
 REPEAT 70 99 ANK 3.
 REPEAT 103 132 ANK 4.
 REPEAT 136 166 ANK 5.  
Keyword
 ANK repeat; Coiled coil; Complete proteome; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH YSTAEVLLRA 60
GVSRDARTKV DRTPLHMAAA DGHAHIVELL VRNGADVNAK DMLKMTALHW ATERHHRDVV 120
ELLIKYGADV HAFSKFDKSA FDIALEKNNA EILVILQEAM QNQVNVNPER ANPVTDPVSM 180
AAPFIFTSGE VVNLASLISS TNTKTTSGDP HASTVQFSNS TTSVLATLAA LAEASVPLSN 240
SHRATANTEE IIEGNSVDSS IQQVMGSGGQ RVITIVTDGV PLGNIQTSIP TGGIGQPFIV 300
TVQDGQQVLT VPAGKVAEET VIKEEEEEKL PLTKKPRIGE KTNSVEESKE GNERELLQQQ 360
LQEANRRAQE YRHQLLKKEQ EAEQYRLKLE AIARQQPNGV DFTMVEEVAE VDAVVVTEGE 420
LEERETKVTG SAGTTEPHTR VSMATVSS 448 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0046982; F:protein heterodimerization activity; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2
 PF13606; Ank_3 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS
 PR01415; ANKYRIN.