CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008909
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycogen [starch] synthase, liver 
Protein Synonyms/Alias
  
Gene Name
 GYS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
381NFNVETLKGQAVRKQubiquitination[1, 2]
387LKGQAVRKQLWDVAHacetylation[3]
397WDVAHSVKEKFGKKLacetylation[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. 
Sequence Annotation
 BINDING 40 40 UDP-glucose (By similarity).
 MOD_RES 6 6 Phosphoserine (By similarity).
 MOD_RES 8 8 Phosphoserine; by PKA (By similarity).
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 626 626 Phosphothreonine (By similarity).
 MOD_RES 641 641 Phosphoserine; by GSK3-alpha and GSK3-
 MOD_RES 645 645 Phosphoserine; by GSK3-alpha and GSK3-
 MOD_RES 649 649 Phosphoserine; by GSK3-alpha and GSK3-
 MOD_RES 653 653 Phosphoserine; by GSK3-alpha and GSK3-
 MOD_RES 657 657 Phosphoserine; by CK2 (By similarity).  
Keyword
 Allosteric enzyme; Complete proteome; Disease mutation; Glycogen biosynthesis; Glycogen storage disease; Glycosyltransferase; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 703 AA 
Protein Sequence
MLRGRSLSVT SLGGLPQWEV EELPVEELLL FEVAWEVTNK VGGIYTVIQT KAKTTADEWG 60
ENYFLIGPYF EHNMKTQVEQ CEPVNDAVRR AVDAMNKHGC QVHFGRWLIE GSPYVVLFDI 120
GYSAWNLDRW KGDLWEACSV GIPYHDREAN DMLIFGSLTA WFLKEVTDHA DGKYVVAQFH 180
EWQAGIGLIL SRARKLPIAT IFTTHATLLG RYLCAANIDF YNHLDKFNID KEAGERQIYH 240
RYCMERASVH CAHVFTTVSE ITAIEAEHML KRKPDVVTPN GLNVKKFSAV HEFQNLHAMY 300
KARIQDFVRG HFYGHLDFDL EKTLFLFIAG RYEFSNKGAD IFLESLSRLN FLLRMHKSDI 360
TVMVFFIMPA KTNNFNVETL KGQAVRKQLW DVAHSVKEKF GKKLYDALLR GEIPDLNDIL 420
DRDDLTIMKR AIFSTQRQSL PPVTTHNMID DSTDPILSTI RRIGLFNNRT DRVKVILHPE 480
FLSSTSPLLP MDYEEFVRGC HLGVFPSYYE PWGYTPAECT VMGIPSVTTN LSGFGCFMQE 540
HVADPTAYGI YIVDRRFRSP DDSCNQLTKF LYGFCKQSRR QRIIQRNRTE RLSDLLDWRY 600
LGRYYQHARH LTLSRAFPDK FHVELTSPPT TEGFKYPRPS SVPPSPSGSQ ASSPQSSDVE 660
DEVEDERYDE EEEAERDRLN IKSPFSLSHV PHGKKKLHGE YKN 703 
Gene Ontology
 GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0043265; C:ectoplasm; ISS:UniProtKB.
 GO:0004373; F:glycogen (starch) synthase activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; TAS:UniProtKB.
 GO:0006006; P:glucose metabolic process; TAS:Reactome.
 GO:0005978; P:glycogen biosynthetic process; IDA:UniProtKB.
 GO:0009749; P:response to glucose stimulus; ISS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR008631; Glycogen_synth. 
Pfam
 PF05693; Glycogen_syn 
SMART
  
PROSITE
  
PRINTS