CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016476
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Hook homolog 1 
Protein Synonyms/Alias
 mHK1 
Gene Name
 Hook1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
678NKSLAFQKLGMESRLubiquitination[1]
693VSGASACKDSVAAAPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. 
Sequence Annotation
 REGION 1 555 Sufficient for interaction with
 REGION 657 728 Sufficient for interaction with AKTIP and
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 235 235 Phosphoserine (By similarity).
 MOD_RES 719 719 Phosphoserine (By similarity).  
Keyword
 3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Direct protein sequencing; Microtubule; Phosphoprotein; Protein transport; Reference proteome; Spermatogenesis; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 728 AA 
Protein Sequence
MEDPQPLPQS ELPLCDSLII WLQTFKTASP CQDVKQLTNG VTMAQVLHQI DVAWFSESWL 60
SRIKDDVGDN WRIKASNLKK VLHGITSYYH EFLGQQISEE LIPDLNQITE CADPVELGRL 120
LQLILGCAVN CEKKQEHIKN IMTLEESVQH VVMTAIQELM SKEIVISPAS DTVGELEQQL 180
KRALEELQEA IAEKEELKQR CQELDMQVTT LQDEKNSLVS ENEMMNEKLD QLDGSFDDPN 240
TMVAKKYFHV QLQLEQLQEE NYRLEAAKDD YRVHCEELEK QLIEFQHRND ELTSLAEETR 300
ALKDEIDVLR ATSDKANKLE STVEVYRQKL QDLNDLRKQV KSLQETNMMY MHNTVSLEEE 360
LKKANAARAQ LETYKRQVQD LHTKLSSESK RADTLAFEMK RLEEKHETLL KEKERLIEQR 420
DTLKETNEEL RCSKAQQDHL NQADASATKS YENLAAEIMP VEYREVFIRL QHENKMLRLQ 480
QEGTENERIE QLQEQLEQKH RKMNELETEQ RLSKERIGEL QQQIEDLQKS LQEQGSKSEG 540
ESSSKLKQKL EAHMEKLTEV HEELQKKQEL IEDLQPDISQ NAQKISELEA ALQKKDEDMK 600
AMEERYKMYL EKARNVIKTL DPKLNPASAE IMLLRKQLAE KERRIEILES ECKVAKLRDY 660
EEKLIVSAWY NKSLAFQKLG MESRLVSGAS ACKDSVAAAP ARSFLAQQRH ITNTRRNLSV 720
KVPAAASD 728 
Gene Ontology
 GO:0070695; C:FHF complex; ISS:UniProtKB.
 GO:0030897; C:HOPS complex; IEA:Compara.
 GO:0005874; C:microtubule; IDA:MGI.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
 GO:0007032; P:endosome organization; ISS:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
 GO:0007040; P:lysosome organization; ISS:UniProtKB.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007286; P:spermatid development; IMP:MGI. 
Interpro
 IPR008636; HOOK/CCDC88. 
Pfam
 PF05622; HOOK 
SMART
  
PROSITE
  
PRINTS