CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021680
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor 7-like 1 
Protein Synonyms/Alias
 HMG box transcription factor 3; TCF-3 
Gene Name
 TCF7L1 
Gene Synonyms/Alias
 TCF3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
358NAFMLYMKEMRAKVVacetylation[1]
363YMKEMRAKVVAECTLacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. 
Sequence Annotation
 DNA_BIND 346 414 HMG box.
 REGION 1 74 CTNNB1-binding (By similarity).
 MOTIF 421 427 Nuclear localization signal (Potential).  
Keyword
 Activator; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 588 AA 
Protein Sequence
MPQLGGGGGG GGGGSGGGGG SSAGAAGGGD DLGANDELIP FQDEGGEEQE PSSDSASAQR 60
DLDEVKSSLV NESENQSSSS DSEAERRPQP VRDTFQKPRD YFAEVRRPQD SAFFKGPPYP 120
GYPFLMIPDL SSPYLSNGPL SPGGARTYLQ MKWPLLDVPS SATVKDTRSP SPAHLSNKVP 180
VVQHPHHMHP LTPLITYSND HFSPGSPPTH LSPEIDPKTG IPRPPHPSEL SPYYPLSPGA 240
VGQIPHPLGW LVPQQGQPMY SLPPGGFRHP YPALAMNASM SSLVSSRFSP HMVAPAHPGL 300
PTSGIPHPAI VSPIVKQEPA PPSLSPAVSV KSPVTVKKEE EKKPHVKKPL NAFMLYMKEM 360
RAKVVAECTL KESAAINQIL GRKWHNLSRE EQAKYYELAR KERQLHSQLY PTWSARDNYG 420
KKKKRKREKQ LSQTQSQQQV QEAEGALASK SKKPCVQYLP PEKPCDSPAS SHGSMLDSPA 480
TPSAALASPA APAATHSEQA QPLSLTTKPE TRAQLALHSA AFLSAKAAAS SSGQMGSQPP 540
LLSRPLPLGS MPTALLASPP SFPATLHAHQ ALPVLQAQPL SLVTKSAH 588 
Gene Ontology
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0008013; F:beta-catenin binding; IBA:RefGenome.
 GO:0003682; F:chromatin binding; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IBA:RefGenome.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IBA:RefGenome.
 GO:0008595; P:anterior/posterior axis specification, embryo; IEA:Compara.
 GO:0048319; P:axial mesoderm morphogenesis; IEA:Compara.
 GO:0007420; P:brain development; IBA:RefGenome.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.
 GO:0006325; P:chromatin organization; NAS:UniProtKB.
 GO:0048699; P:generation of neurons; IBA:RefGenome.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0046022; P:positive regulation of transcription from RNA polymerase II promoter during mitosis; IEA:Compara.
 GO:2000036; P:regulation of stem cell maintenance; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0030111; P:regulation of Wnt receptor signaling pathway; NAS:UniProtKB.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR027397; Catenin_binding_dom.
 IPR013558; CTNNB1-bd_N.
 IPR009071; HMG_box_dom.
 IPR024940; TCF/LEF. 
Pfam
 PF08347; CTNNB1_binding
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS