CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017719
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetraspanin-14 
Protein Synonyms/Alias
 Tspan-14; DC-TM4F2; Transmembrane 4 superfamily member 14 
Gene Name
 TSPAN14 
Gene Synonyms/Alias
 TM4SF14 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52GVLSDLTKVTRMHGIubiquitination[1]
179GASYSREKCGVPFSCubiquitination[2]
194CVPDPAQKVVNTQCGubiquitination[1]
211VRIQLKSKWDESIFTubiquitination[1]
265ISDIEAVKAGHHF**ubiquitination[1, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 270 AA 
Protein Sequence
MHYYRYSNAK VSCWYKYLLF SYNIIFWLAG VVFLGVGLWA WSEKGVLSDL TKVTRMHGID 60
PVVLVLMVGV VMFTLGFAGC VGALRENICL LNFFCGTIVL IFFLELAVAV LAFLFQDWVR 120
DRFREFFESN IKSYRDDIDL QNLIDSLQKA NQCCGAYGPE DWDLNVYFNC SGASYSREKC 180
GVPFSCCVPD PAQKVVNTQC GYDVRIQLKS KWDESIFTKG CIQALESWLP RNIYIVAGVF 240
IAISLLQIFG IFLARTLISD IEAVKAGHHF 270 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 
Pfam
 PF00335; Tetraspannin 
SMART
  
PROSITE
 PS00421; TM4_1 
PRINTS
 PR00259; TMFOUR.