UniProt Accession

 SKI8_YEAST; Q02793; D6VTU2 

Genbank Protein ID

 M96058; Z72736; BK006941 

Genbank Nucleotide ID

 AAA35050.1; CAA96930.1; DAA07903.1 

Protein Name

 Antiviral protein SKI8 

Protein Synonyms/Alias

 Superkiller protein 8 

Gene Name

 SKI8 

Gene Synonyms/Alias

 REC103; YGL213C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
147	RLVATDVKGTTYIWK	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology. 

Sequence Annotation

 REPEAT 21 42 WD 1.
 REPEAT 67 101 WD 2.
 REPEAT 126 157 WD 3.
 REPEAT 191 213 WD 4.
 REPEAT 238 264 WD 5.
 REPEAT 296 319 WD 6.
 REPEAT 359 392 WD 7.  

Keyword

 3D-structure; Antiviral defense; Chromosome; Complete proteome; Cytoplasm; Meiosis; Nucleus; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 397 AA 

Protein Sequence

Gene Ontology

 GO:0000228; C:nuclear chromosome; IDA:SGD.
 GO:0055087; C:Ski complex; IDA:SGD.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IMP:SGD.
 GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IMP:SGD.
 GO:0006461; P:protein complex assembly; IMP:SGD.
 GO:0065004; P:protein-DNA complex assembly; IMP:SGD.
 GO:0007131; P:reciprocal meiotic recombination; IMP:SGD. 

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS