| Tag | Content |
|---|
| CPLM ID | CPLM-011603 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leukotriene-B(4) omega-hydroxylase 2 |
Protein Synonyms/Alias | CYPIVF3; Cytochrome P450 4F3; Cytochrome P450-LTB-omega; Leukotriene-B(4) 20-monooxygenase 2 |
Gene Name | CYP4F3 |
Gene Synonyms/Alias | LTB4H |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 294 | LQAKAKSKTLDFIDV | ubiquitination | [1] | | 306 | IDVLLLSKDEDGKKL | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH. Isoform CYP4F3A catalyzes the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. |
Sequence Annotation | METAL 468 468 Iron (heme axial ligand) (By similarity).
BINDING 328 328 Heme (covalent; via 1 link) (By |
Keyword | Alternative promoter usage; Alternative splicing; Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 520 AA |
Protein Sequence | MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF 60
LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK 120
DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL 180
LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL 240
LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 300
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE 360
LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC 420
LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV 480
VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS 520 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0052871; F:alpha-tocopherol omega-hydroxylase activity; IEA:EC. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0050051; F:leukotriene-B4 20-monooxygenase activity; IEA:EC. GO:0004497; F:monooxygenase activity; TAS:ProtInc. GO:0019369; P:arachidonic acid metabolic process; TAS:Reactome. GO:0036101; P:leukotriene B4 catabolic process; IEA:GOC. GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |