UniProt Accession

 IL32_HUMAN; P24001; A6NNM0; A8MPX0; B4DJM1; D3DUB0; D3DUB2; Q5VFH7; Q5VFH8; Q8WV38; Q96GK9 

Genbank Protein ID

 M59807; AY495331; AY495332; AY495333; AY495334; AY495334; AY495334; AK296143; BM825040; AC108134; CH471112; CH471112; CH471112; CH471112; CH471112; CH471112; BC009401; BC018782; BC105602 

Genbank Nucleotide ID

 AAA36367.2; AAS80143.1; AAS80144.1; AAS80145.1; AAS80146.1; AAS80147.1; AAS80148.1; BAG58883.1; EAW85405.1; EAW85406.1; EAW85407.1; EAW85408.1; EAW85409.1; EAW85410.1; AAH09401.1; AAH18782.1; AAI05603.1 

Protein Name

 Interleukin-32 

Protein Synonyms/Alias

 IL-32; Natural killer cells protein 4; Tumor necrosis factor alpha-inducing factor 

Gene Name

 IL32 

Gene Synonyms/Alias

 NK4; TAIF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	KVLSDDMKKLKARMV	ubiquitination	[1]
13	VLSDDMKKLKARMVM	ubiquitination	[1]
51	HLGPWRDKDPALWCQ	ubiquitination	[1]
74	AIERFYDKMQNAESG	ubiquitination	[1, 2, 3, 4]
153	PGESFCDKVMRWFQA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF- alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Cytokine; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 234 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0006952; P:defense response; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS