CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005235
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Periplasmic dipeptide transport protein 
Protein Synonyms/Alias
 Dipeptide-binding protein; DBP 
Gene Name
 dppA 
Gene Synonyms/Alias
 b3544; JW3513 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
81VIPGLAEKWEVSEDGacetylation[1]
89WEVSEDGKTYTFHLRacetylation[1]
134NAQNPYHKVSGGSYEacetylation[1]
196EYADAMMKAGTPEKLacetylation[1]
202MKAGTPEKLDLNPIGacetylation[1]
220FQLQQYQKDSRIRYKacetylation[1]
227KDSRIRYKAFDGYWGacetylation[1]
259VRYAKLQKNECQVMPacetylation[1]
280IARMKQDKSINLMEMacetylation[1]
319ALTYAVNKDAIIKAVacetylation[1]
358DYTYDPEKAKALLKEacetylation[1]
402MIQADWAKVGVQAKIacetylation[1]
465NYSKWCYKPFEDLIQacetylation[1, 2]
526YVVDPLGKHHFENVSacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 
Functional Description
 Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis. 
Sequence Annotation
 DISULFID 34 262
 DISULFID 450 463  
Keyword
 3D-structure; Chemotaxis; Complete proteome; Direct protein sequencing; Disulfide bond; Peptide transport; Periplasm; Protein transport; Reference proteome; Signal; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 535 AA 
Protein Sequence
MRISLKKSGM LKLGLSLVAM TVAASVQAKT LVYCSEGSPE GFNPQLFTSG TTYDASSVPL 60
YNRLVEFKIG TTEVIPGLAE KWEVSEDGKT YTFHLRKGVK WHDNKEFKPT RELNADDVVF 120
SFDRQKNAQN PYHKVSGGSY EYFEGMGLPE LISEVKKVDD NTVQFVLTRP EAPFLADLAM 180
DFASILSKEY ADAMMKAGTP EKLDLNPIGT GPFQLQQYQK DSRIRYKAFD GYWGTKPQID 240
TLVFSITPDA SVRYAKLQKN ECQVMPYPNP ADIARMKQDK SINLMEMPGL NVGYLSYNVQ 300
KKPLDDVKVR QALTYAVNKD AIIKAVYQGA GVSAKNLIPP TMWGYNDDVQ DYTYDPEKAK 360
ALLKEAGLEK GFSIDLWAMP VQRPYNPNAR RMAEMIQADW AKVGVQAKIV TYEWGEYLKR 420
AKDGEHQTVM MGWTGDNGDP DNFFATLFSC AASEQGSNYS KWCYKPFEDL IQPARATDDH 480
NKRVELYKQA QVVMHDQAPA LIIAHSTVFE PVRKEVKGYV VDPLGKHHFE NVSIE 535 
Gene Ontology
 GO:0043190; C:ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc.
 GO:0030288; C:outer membrane-bounded periplasmic space; EXP:EcoCyc.
 GO:0042936; F:dipeptide transporter activity; IGI:EcoCyc.
 GO:0042277; F:peptide binding; IDA:EcoCyc.
 GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR000914; SBP_bac_5.
 IPR023765; SBP_bac_5_CS. 
Pfam
 PF00496; SBP_bac_5 
SMART
  
PROSITE
 PS01040; SBP_BACTERIAL_5 
PRINTS