CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007438
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low-affinity Fe(2+) transport protein 
Protein Synonyms/Alias
 Low-affinity Fe(II) transport protein 
Gene Name
 FET4 
Gene Synonyms/Alias
 YMR319C; YM9924.11C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
39FGDSNDYKNDDVVRVubiquitination[1, 2]
180RSTPEEEKADCTVEAubiquitination[2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Required for Fe(2+) ion low affinity uptake. 
Sequence Annotation
 MOD_RES 48 48 Phosphoserine.
 MOD_RES 50 50 Phosphoserine.  
Keyword
 Complete proteome; Ion transport; Iron; Iron transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 552 AA 
Protein Sequence
MGKIAEFLGN PGARPDVHHR APTVDCKQYE EFGDSNDYKN DDVVRVVSHS DESTDDELCN 60
VNLTETGAIF TSKGFTGLSK GFTDKTLDFL VRVAGSQAVF FIVWIILIIW VVIGIVYNAP 120
FNWQVVMQDG QSIQSYVWDT LLMRQQLMST HEQILICGRL KSRLASFKNY LTRSTPEEEK 180
ADCTVEANEV SSVENHIDPS AINGELPVEN WYDRLSNVAS RYMGSIAAMV IFWIGIFVWI 240
GCGAIPKDAG NTPPYTGETT GSNPRLKKFS DAWQMYINTA VAVSLLICTT FLQNIRARHD 300
YFTGRFLVDI FDMDEKIDYR IRKHFNDFET PHPVVTIESK KRSTGRKMID WYADIIGTGI 360
GVLIGVAVFA TWIGIGSPMK WDDNWWLIIG TYTGLIGFLD GFVLREVYFR IVQHEEKNYS 420
DVAKEDLELF QELGIECPEE FSGKAPEINT IGYRTSQYIN RICSTPWSVL VSVIIIIGLI 480
CIASGLRWST TGQLIANTPT MIIEEFFLLV LLQAHNWADR QRRVEVTALY ARRRILLSYV 540
EKRFPEVMML EK 552 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IDA:SGD.
 GO:0005375; F:copper ion transmembrane transporter activity; IMP:SGD.
 GO:0005381; F:iron ion transmembrane transporter activity; IMP:SGD.
 GO:0015677; P:copper ion import; IMP:SGD.
 GO:0015680; P:intracellular copper ion transport; IMP:SGD.
 GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
 GO:0000040; P:low-affinity iron ion transport; IMP:SGD.
 GO:0006829; P:zinc ion transport; IMP:SGD. 
Interpro
 IPR007251; Iron_permease_Fet4. 
Pfam
 PF04120; Iron_permease 
SMART
  
PROSITE
  
PRINTS