CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020209
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methyltransferase-like protein 22 
Protein Synonyms/Alias
  
Gene Name
 METTL22 
Gene Synonyms/Alias
 C16orf68; LP8272 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
184TPLEDVGKQVWRGALubiquitination[1]
264GGGIVRVKELDWLKDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Protein N-lysine methyltransferase. In vitro methylates KIN. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Methyltransferase; Nucleus; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 404 AA 
Protein Sequence
MVQLAPAAAM DEVTFRSDTV LSDVHLYTPN HRHLMVRLNS VGQPVFLSQF KLLWSQDSWT 60
DSGAKGGSHR DVHTKEPPSA ETGSTGSPPG SGHGNEGFSL QAGTDTTGQE VAEAQLDEDG 120
DLDVVRRPRA ASDSNPAGPL RDKVHPMILA QEEDDVLGEE AQGSPHDIIR IEHTMATPLE 180
DVGKQVWRGA LLLADYILFR QDLFRGCTAL ELGAGTGLAS IIAATMARTV YCTDVGADLL 240
SMCQRNIALN SHLAATGGGI VRVKELDWLK DDLCTDPKVP FSWSQEEISD LYDHTTILFA 300
AEVFYDDDLT DAVFKTLSRL AHRLKNACTA ILSVEKRLNF TLRHLDVTCE AYDHFRSCLH 360
ALEQLADGKL RFVVEPVEAS FPQLLVYERL QQLELWKIIA EPVT 404 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. 
Interpro
 IPR019410; Nicotinamide_N-MeTfrase-like. 
Pfam
 PF10294; Methyltransf_16 
SMART
  
PROSITE
  
PRINTS