CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022604
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sulfotransferase family cytosolic 1B member 1 
Protein Synonyms/Alias
 ST1B1; Sulfotransferase 1B1; DOPA/tyrosine sulfotransferase 
Gene Name
 Sult1b1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
107TPSPRIIKTHLPIDLubiquitination[1]
253TAMMDHSKSPFMRKGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates L-DOPA and D-DOPA, tyrosine isomers such as DL-m-tyrosine, dopamine and thyroid hormones. 
Sequence Annotation
 NP_BIND 48 53 PAPS (By similarity).
 NP_BIND 228 233 PAPS (By similarity).
 NP_BIND 258 260 PAPS (By similarity).
 ACT_SITE 109 109 Proton acceptor (By similarity).
 BINDING 131 131 PAPS (By similarity).
 BINDING 139 139 PAPS (By similarity).
 BINDING 194 194 PAPS (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Lipid metabolism; Reference proteome; Steroid metabolism; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
MSASEDVWRK DLKMIHGYPM IYAFALNWER IEEFQSTPGD IVITTYPKSG TTWLSEIVDM 60
VLNDGNVEKC KRDVITSKVP MLELSVPGIR ISGVELLKKT PSPRIIKTHL PIDLLPKSFW 120
ENKCKMIYLA RNGKDVAVSY YHFDLMNSIN PLPGTWEEYL EKFLAGNVAY GSWFDHVKSW 180
WEKREEHPLL YLYYEELKQN PKKEIKKIAS FLDKTLDEEA LDRIVHHTSF EMMKENPLVN 240
YTHLPTAMMD HSKSPFMRKG IVGDWKNYFT MTQTEQFDAV YKKKMSGTTL EFCTDIQSAL 300
NFTNFEIIIG FSLKFS 316 
Gene Ontology
 GO:0005829; C:cytosol; TAS:MGI.
 GO:0004062; F:aryl sulfotransferase activity; IDA:MGI.
 GO:0009812; P:flavonoid metabolic process; IEA:Compara.
 GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
 GO:0051923; P:sulfation; IEA:Compara.
 GO:0042403; P:thyroid hormone metabolic process; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; IEA:Compara. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 
Pfam
 PF00685; Sulfotransfer_1 
SMART
  
PROSITE
  
PRINTS