UniProt Accession

 B4DWF2_HUMAN; B4DWF2 

Genbank Protein ID

 AC013736; AC079610; AC108066; AK301503; CH471063 

Genbank Nucleotide ID

 BAG63014.1; EAW70505.1 

Protein Name

 Zinc finger protein Helios 

Protein Synonyms/Alias

 Zinc finger protein, subfamily 1A, 2 (Helios), isoform CRA_d; cDNA FLJ55795, highly similar to Zinc finger protein Helios 

Gene Name

 ZNFN1A2 

Gene Synonyms/Alias

 IKZF2; hCG_14830 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	SEVADNRKVQELQGE	ubiquitination	[1]
117	GIRLPNGKLKCDVCG	acetylation	[1]
166	GNLLRHIKLHSGEKP	ubiquitination	[2]
172	IKLHSGEKPFKCPFC	acetylation	[1]
172	IKLHSGEKPFKCPFC	ubiquitination	[2]
274	ERPAVIEKLTGNMGK	ubiquitination	[1]
289	RKSSTPQKFVGEKLM	ubiquitination	[1, 2, 3]
294	PQKFVGEKLMRFSYP	acetylation	[1]
294	PQKFVGEKLMRFSYP	ubiquitination	[1, 2, 3]
444	KQSPAYMKEDVKALD	ubiquitination	[1, 2]
448	AYMKEDVKALDTTKA	ubiquitination	[1, 2]
454	VKALDTTKAPKGSLK	ubiquitination	[1, 2]
457	LDTTKAPKGSLKDIY	ubiquitination	[1]
461	KAPKGSLKDIYKVFN	ubiquitination	[1, 2]
465	GSLKDIYKVFNGEGE	ubiquitination	[1, 2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 532 AA 

Protein Sequence

Gene Ontology

 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS