UniProt Accession

 CDN1B_MOUSE; P46414; Q8BG74 

Genbank Protein ID

 U10440; U09968; AK046676; AK047669; AK050240; AC122193; BC014296 

Genbank Nucleotide ID

 AAA21149.1; AAA20235.1; BAC32833.1; BAC33119.1; BAC34141.1; AAH14296.1 

Protein Name

 Cyclin-dependent kinase inhibitor 1B 

Protein Synonyms/Alias

 Cyclin-dependent kinase inhibitor p27; p27Kip1 

Gene Name

 Cdkn1b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
100	RPPKSACKVLAQESQ	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of cyclin D-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. 

Sequence Annotation

 MOTIF 153 169 Nuclear localization signal (Potential).
 MOD_RES 10 10 Phosphoserine; by UHMK1.
 MOD_RES 74 74 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 88 88 Phosphotyrosine; by ABL, LYN, SRC and
 MOD_RES 89 89 Phosphotyrosine (By similarity).
 MOD_RES 187 187 Phosphothreonine; by PKB/AKT1 and CDK2.
 MOD_RES 197 197 Phosphothreonine; by PKB/AKT1, RPS6KA1,  

Keyword

 Cell cycle; Complete proteome; Cytoplasm; Endosome; Nucleus; Phosphoprotein; Protein kinase inhibitor; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IDA:MGI.
 GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IEA:Compara.
 GO:0048102; P:autophagic cell death; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IDA:MGI.
 GO:0071236; P:cellular response to antibiotic; IDA:MGI.
 GO:0071285; P:cellular response to lithium ion; ISO:MGI.
 GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IDA:UniProtKB.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0048839; P:inner ear development; IMP:MGI.
 GO:0071850; P:mitotic cell cycle arrest; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0051271; P:negative regulation of cellular component movement; IDA:MGI.
 GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:MGI.
 GO:0060770; P:negative regulation of epithelial cell proliferation involved in prostate gland development; IMP:MGI.
 GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0031116; P:positive regulation of microtubule polymerization; IGI:MGI.
 GO:0045732; P:positive regulation of protein catabolic process; IEA:Compara.
 GO:0006813; P:potassium ion transport; IGI:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI. 

Interpro

 IPR003175; CDI. 

Pfam

 PF02234; CDI 

SMART

  

PROSITE

  

PRINTS