| Tag | Content |
|---|
| CPLM ID | CPLM-010495 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dermcidin |
Protein Synonyms/Alias | Preproteolysin; Survival-promoting peptide; DCD-1 |
Gene Name | DCD |
Gene Synonyms/Alias | AIDD; DSEP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 68 | QRSSLLEKGLDGAKK | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. |
Sequence Annotation | MOD_RES 68 68 N6-acetyllysine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Antibiotic; Antimicrobial; Complete proteome; Direct protein sequencing; Fungicide; Hydrolase; Manganese; Protease; Reference proteome; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 110 AA |
Protein Sequence | MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG LARQAPKPRK 60
QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH DVKDVLDSVL 110 |
Gene Ontology | GO:0005576; C:extracellular region; IDA:UniProtKB. GO:0008233; F:peptidase activity; IEA:UniProtKB-KW. GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW. GO:0031640; P:killing of cells of other organism; IEA:UniProtKB-KW. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
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PRINTS | |