CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038771
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Anthrax toxin receptor 1 
Protein Synonyms/Alias
  
Gene Name
 Atr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2205LTKAIHMKKSLEKFVacetylation[1]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2641 AA 
Protein Sequence
MGDHGLELAS MIPALRELAS ATPEEYNTVV QKPRQILCQF IDRILTDVNV VALELVKKTD 60
AQPTSVMLLD FIQHIMKSSP LMFVNVNGSQ GQNEAKDSCI EFSHWIITRL LRIAATPSCH 120
MLHKKICEVI CSLLFLFKSK NPAIFGVLTR ELLYLFEDLI YLHKRNAVGE VMEWPVVVSR 180
FLSRLDEHMG CLQPAPLQFM NVQNVEFIEV TLLMVLIHIV PTVFFRRQEL LLWQIGCALL 240
EHGSPKIRSL AISLLTELFE LGGLPAQPAS TFFSLFLELL QHLVGMDADQ LKLYEEPLSK 300
LLKTLFPFEA EAYRNIEPVY LNVLLEKLSV MFEDRVLMRL KSDLLKAALC HLLQYFLTFV 360
PAGYESALQV RKVYVTNICR ALVDALGVQK HVGYLLGPFY AALKMESKEI IERIQCQAQQ 420
ENLSGNNDEV SPKRRKLSSS LSSYKKPSRQ PEEIIHVDMD KKSILWNVLK QKAESLQISL 480
ECGTLKNSVA EALEGITVVL QLTALCTVHC SHQDMDGHNV KDHQHKYKKK PPVVVTWMSL 540
DFYTKVLKSC RSLLESVQKL ELELVIDSMV RICDALMYMQ VKSSFKDHVL EELCGMLSLP 600
WIYSYSDDNS LKMTTFATNL LPLSQRVWDS YSPQAQSKCV FLLTLFPRRI FLEWRTAVYN 660
WALKSSHEVI RASCVKGFFI LLHQQNSCNQ IPKMLVDRVK DDSDMVKKEF ASVLGQLVCT 720
LHGMFYLSSS VEPCFEHMDL FSKNLKATSQ HECSSSQVKA STCKPFLFLL TKNTPSPVKL 780
AFIDNLHHLC KHLDFQEDER EVKAVLGTLL NLMEDPDKDV RIAFSGNIKY ILESLNSEDG 840
FVKELFVLRM KEAYTHAQIA RNNELKDTLI LTTGDIGRAA KGDLIPFALL HLLHCLLSKS 900
ASVSGAAYTE IRALVAAKSV KLQNFFSQYK KPICQFLVES LHSSQMTALP SAPCQSSEIR 960
KQDVAHHREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP DLAAKASPAA SALIRTLGKQ 1020
LNVSRREILI NNFKYIFSHL VCSCSKDELE RALHYLKNET EIELGSLLRQ DFQGLHNELL 1080
LRIGEHYQQV FNGLSILASF ASSDDPYQGP RDITSPELMA DYLQPKLLGI LAFFNMQLLS 1140
SSVGIEDKKM ALTSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV 1200
RCLDHAYLGP LLSHVIVALL PLIHMQPKET AAIFHYLIIE NRDAVQDFLH EIYFLPDHPE 1260
LEKIKAVLQE YRKETSETTD LQTTLQLSMK AIQHENVDVR IHALTSLKET LYKNQEKLIK 1320
YATDSETVEP VISQLVTVIL KGCQDANSQA RLLCGECLGE LGAIDPGRLD FSTTETQGKD 1380
FTFVTGVEDL SFAYGLLMEL TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMQSNGPGY 1440
QLWKRFPEHV REILEPHLNT RYKSSQKSTD WSGVTKPIYL SKLGNNFAEW SSSWAGYLIT 1500
KVRDNLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA EIMAVLKHDE 1560
QHAISTQDSA SDLCQLSTQT VFSVLDHLTQ WARHKFQALN AEKLAQNKPK GGKVNKILSN 1620
VNFEDYQSVT RFLDLIPQDT LAVASFRSKA YTRAVMHFES FITEKKQNIQ KHLGFLQKLY 1680
AAMHEPDGVA GVSAIRKAEP SLKEQILEHE SIGLLRDATA CYDRAIQLEP DQIIHYHGVV 1740
KSMLGLGQLS TVITQVNGVH ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW 1800
SVRLGQLLLS AKKRDTTTFY DTLKLVRAEQ IVPLSAASFE RGSYQRGYEF IVRLHMLCEL 1860
EHSLKPLFRK SPGDSCNEDS LNWGARLEMT QNSYRAKEPI LALRRALLSL NKRPDYNEMV 1920
GECWLQSARV ARKAGHHQTA YNALLNAGES RLAELYVERA KWLWSKGDVH QALIVLQKGV 1980
ELCFPENKSP SESKHMLIHG RATLLVGRFM EETANFESNA VMKKYKDVTL FLPEWEDGHF 2040
YLAKYYDKLM PMVTDNKMEK QGDLIRYIVL HFGRSLQYGN QFIYQSMPRM LSLWLDFGAK 2100
AYEWEKGGRS DRLQMRNDLA KINSVLTEHT NRLAPYQFLT AFSQLISRIC HSHDEVFVVL 2160
MEIIAKVFLA YPQQAMWMMT AVSKSSYPMR VNRCKEILTK AIHMKKSLEK FVGDATRLTD 2220
KLLELCNKSV DGSNSTLSMS THFKMLKRLV EDPTFSEILI PLQSVMIPTL PSVLGAHANH 2280
DPFPGHWAYL AGFDDVVEIL SSLQKPKKIS LKGSDGKFYI MMCKPKDDLR KDCRLMEFNS 2340
LINKSLRKDA ESRRRELHIR TYAVIPLNDE CGIIEWVNNT AGLRPILTKI YKEKGVYMTG 2400
KELRQCMLPK SAALSEKLKV FQELLLPRHP PVFHEWFLRT FPDPTSWYSS RSAYCRSTAV 2460
MSMVGYILGL GDRHGENILF DSFTGECVHV DFNCLFNKGE TFEVPEIVPF RLTHNMVNGM 2520
GPMGTEGLFR RACEVTLRLM RDQREPLMSV LKTFLHDPLV EWSKPVKGHS KAPLNETGEV 2580
VNEKAKTHVL DIEQRLQGVI KTRNRVTGLP LSIEGHVHYL IQEATDENLL CQMYLGWTPY 2640
M 2641 
Gene Ontology
 GO:0005634; C:nucleus; TAS:MGI.
 GO:0001741; C:XY body; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; IDA:MGI.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:Compara.
 GO:0071480; P:cellular response to gamma radiation; IEA:Compara.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0000077; P:DNA damage checkpoint; IMP:MGI.
 GO:0006281; P:DNA repair; IDA:MGI.
 GO:0008156; P:negative regulation of DNA replication; IEA:Compara.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0043393; P:regulation of protein binding; IDA:MGI.
 GO:0090399; P:replicative senescence; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR021133; HEAT_type_2.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR003151; PIK-rel_kinase_FAT.
 IPR014009; PIK_FAT.
 IPR011990; TPR-like_helical.
 IPR012993; UME. 
Pfam
 PF02259; FAT
 PF02260; FATC
 PF00454; PI3_PI4_kinase
 PF08064; UME 
SMART
 SM00146; PI3Kc
 SM00802; UME 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS50077; HEAT_REPEAT
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS