CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007477
UniProt Accession
Genbank Protein ID
 X75927 
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 2 
Protein Synonyms/Alias
 ATP-binding cassette transporter 2; ATP-binding cassette 2 
Gene Name
 Abca2 
Gene Synonyms/Alias
 Abc2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1336ENSEADVKESRKDVLubiquitination[1]
1340ADVKESRKDVLPGAEubiquitination[1]
2026QRLPVSTKPVEDDVDubiquitination[1]
2178LEKLELTKYADKPAGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. 
Sequence Annotation
 DOMAIN 990 1221 ABC transporter 1.
 DOMAIN 2051 2286 ABC transporter 2.
 NP_BIND 1024 1031 ATP 1 (Potential).
 NP_BIND 2088 2095 ATP 2 (Potential).
 MOD_RES 1327 1327 Phosphoserine.
 MOD_RES 1331 1331 Phosphoserine.
 MOD_RES 2411 2411 Phosphothreonine (By similarity).
 CARBOHYD 14 14 N-linked (GlcNAc...) (Potential).
 CARBOHYD 89 89 N-linked (GlcNAc...) (Potential).
 CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 305 305 N-linked (GlcNAc...) (Potential).
 CARBOHYD 368 368 N-linked (GlcNAc...) (Potential).
 CARBOHYD 379 379 N-linked (GlcNAc...) (Potential).
 CARBOHYD 420 420 N-linked (GlcNAc...) (Potential).
 CARBOHYD 432 432 N-linked (GlcNAc...) (Potential).
 CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
 CARBOHYD 484 484 N-linked (GlcNAc...) (Potential).
 CARBOHYD 494 494 N-linked (GlcNAc...) (Potential).
 CARBOHYD 530 530 N-linked (GlcNAc...) (Potential).
 CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 589 589 N-linked (GlcNAc...) (Potential).
 CARBOHYD 599 599 N-linked (GlcNAc...) (Potential).
 CARBOHYD 627 627 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1408 1408 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1496 1496 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1549 1549 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1557 1557 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1613 1613 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1678 1678 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1776 1776 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2055 2055 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Complete proteome; Endosome; Glycoprotein; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2434 AA 
Protein Sequence
MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS VKEAFYTAAP 60
LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLH RVVEEGNLFD PVRPSLGSEL 120
EALRQRLEAL SSGPGTWESH SARPAVSSFS LDSVARDQRE LWRFLMQNLS LPNSTAQALL 180
AARVDPSEVY RLLFGPLPDL DGKLGFLRKQ EPWSRLGSNP LLQMEELLLA PALLEQLTCA 240
PGSGELGRIL TMPEGHQVDL QGYRDAVCSG QATARAQRFS DLAAELRNQL DTAKIAQQLG 300
FDVPNGSDPQ PQAPSPQSLP ALLGDLLDAQ KLLQDVDVLS ALALLLPQGA CAGQASAPQA 360
SSLNGLANST GIGANSGSNT TVEEGTQSPV SPASPDTLQG QCSAFVQLWA GLQPILCGNN 420
RTIEPEALRR GNMSSLGFTS KEQRNLGLLV HLMTSNPKIL YAPVGSEADR VILKANETFA 480
FVGNVTHYAQ VWLNISTEIR SFLEQGRLQQ HLQWLQQYVA DLQLHPEAMN LSLEELPPAL 540
RQDFSLPNGT ALLQQLDTID NAACGWIQFM SKVSVDIFKG FPDEESIVNY TLNQAYQDNV 600
TVFASVIFQT RKDGSLPPHV HYKIRQNSSF TEKTNEIRRA YWRPGPNTGG RFYFLYGLRL 660
DQDMMERAII NTFVGHDVVE PGNYVQMFPY PCYTRDDFLF VIEHMMPLCM VISWVYSVAM 720
TIQHIVAEKE HRLKEVMKTM GLNNAVHWVA WFITGFVQLS ISVTALTAIL KYCQVLMHSH 780
VLIIWLFLAV YAVATIMFCF LVSVLYSKAK LASACGGIIY FLSYVPYMYV AIREEVAHDK 840
ITAFEKCIAS RCPQQPLAWV PSTLHCMKWQ EWASIQWHTF SQSPVEGDDF NLLLAVTMLM 900
VDTVVYGVLT WYIEAVHPGM YGLPRPWYSR YRSPIGWAVG GQKPGSGAGH GHTHRASALW 960
RRIQACAMES RHFEETRGME EEPTHLPLVV CVDKLTKVYK NDKKLALNKL SLNLYENQVV 1020
SFLGHNGAGK TTTMSILTGL FPPTSGSATI YGHDIRTEMD EIRKNLGMCP QHNVLFDRLT 1080
VEEHLWFYSR LKSMAQEEIR KETDKMIEDL ELSNKRHSLV QTLSGGMKRK LSVAIAFVGG 1140
SRAIILDEPT AGVDPYARRA IWDLILKYKP GRTILLSTHH MDEADLLGDR IAIISHGKLK 1200
CCGSPLFLKG AYGDGYRLTL VKQPAEPGTS QEPGLASSPS GCPRLSSCSE PQVSQFIRKH 1260
VASSLLVSDT STELSYILPS EAVKKGAFER LFQQLEHSLD ALHLSSFGLM DTTLEEVFLK 1320
VSEEDQSLEN SEADVKESRK DVLPGAEGLT AVGGQAGNLA RCSELAQSQA SLQSASSVGS 1380
ARGEEGTGYS DGYGDYRPLF DNLQDPDNVS LQEAEMEALA QVGQGSRKLE GWWLKMRQFH 1440
GLLVKRFHCA RRNSKALCSQ ILLPAFFVCV AMTVALSVPE IGDLPPLVLS PSQYHNYTQP 1500
RGNFIPYANE ERQEYRLRLS PDASPQQLVS TFRLPSGVGA TCVLKSPANG SLGPMLNLSS 1560
GESRLLAARF FDSMCLESFT QGLPLSNFVP PPPSPAPSDS PVSPDEDSLQ AWNMSLPPTA 1620
GPETWTSAPS LPRLVHEPVR CTCSAQGTGF SCPSSVGGHP PQMRVVTGDI LTDITGHNVS 1680
EYLLFTSDRF RLHRYGAITF GNVQKSIPAS FGARVPPMVR KIAVRRVAQV LYNNKGYHSM 1740
PTYLNSLNNA ILRANLPKSK GNPAAYGITV TNHPMNKTSA SLSLDYLLQG TDVVIAIFII 1800
VAMSFVPASF VVFLVAEKST KAKHLQFVSG CNPVIYWLAN YVWDMLNYLV PATCCVIILF 1860
VFDLPAYTSP TNFPAVLSLF LLYGWSITPI MYPASFWFEV PSSAYVFLIV INLFIGITAT 1920
VATFLLQLFE HDKDLKVVNS YLKSCFLIFP NYNLGHGLME MAYNEYINEY YAKIGQFDKM 1980
KSPFEWDIVT RGLVAMTVEG FVGFFLTIMC QYNFLRQPQR LPVSTKPVED DVDVASERQR 2040
VLRGDADNDM VKIENLTKVY KSRKIGRILA VDRLCLGVRP GECFGLLGVN GAGKTSTFKM 2100
LTGDESTTGG EAFVNGHSVL KDLLQVQQSL GYCPQFDALF DELTAREHLQ LYTRLRGIPW 2160
KDEAQVVKWA LEKLELTKYA DKPAGTYSGG NKRKLSTAIA LIGYPAFIFL DEPTTGMDPK 2220
ARRFLWNLIL DLIKTGRSVV LTSHSMEECE ALCTRLAIMV NGRLRCLGSI QHLKNRFGDG 2280
YMITVRTKSS QNVKDVVRFF NRNFPEAMLK ERHHTKVQYQ LKSEHISLAQ VFSKMEQVVG 2340
VLGIEDYSVS QTTLDNVFVN FAKKQSDNVE QQEAEPSSLP SPLGLLSLLR PRPAPTELRA 2400
LVADEPEDLD TEDEGLISFE EERAQLSFNT DTLC 2434 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISS:UniProtKB.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; ISS:UniProtKB.
 GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
 GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0016887; F:ATPase activity; ISS:UniProtKB.
 GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
 GO:0032383; P:regulation of intracellular cholesterol transport; ISS:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0048545; P:response to steroid hormone stimulus; ISS:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS