CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000345
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 
Protein Synonyms/Alias
 SERCA1; SR Ca(2+)-ATPase 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase 
Gene Name
 ATP2A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
120ENAIEALKEYEPEMGubiquitination[1]
128EYEPEMGKVYRADRKubiquitination[1]
252DKTPLQQKLDEFGEQubiquitination[1]
515VGNKMFVKGAPEGVIubiquitination[1]
758RAIYNNMKQFIRYLIubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. 
Sequence Annotation
 REGION 370 400 Interacts with phospholamban 1 (By
 REGION 788 808 Interacts with phospholamban 2 (By
 ACT_SITE 351 351 4-aspartylphosphate intermediate (By
 METAL 304 304 Calcium 2; via carbonyl oxygen (By
 METAL 305 305 Calcium 2; via carbonyl oxygen (By
 METAL 307 307 Calcium 2; via carbonyl oxygen (By
 METAL 309 309 Calcium 2 (By similarity).
 METAL 703 703 Magnesium (By similarity).
 METAL 707 707 Magnesium (By similarity).
 METAL 768 768 Calcium 1 (By similarity).
 METAL 771 771 Calcium 1 (By similarity).
 METAL 796 796 Calcium 2 (By similarity).
 METAL 799 799 Calcium 1 (By similarity).
 METAL 800 800 Calcium 1 (By similarity).
 METAL 800 800 Calcium 2 (By similarity).
 METAL 908 908 Calcium 1 (By similarity).
 DISULFID 876 888  
Keyword
 Alternative splicing; ATP-binding; Calcium; Calcium transport; Complete proteome; Disease mutation; Disulfide bond; Endoplasmic reticulum; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1001 AA 
Protein Sequence
MEAAHAKTTE ECLAYFGVSE TTGLTPDQVK RNLEKYGLNE LPAEEGKTLW ELVIEQFEDL 60
LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 120
EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILAIKS TTLRVDQSIL 180
TGESVSVIKH TEPVPDPRAV NQDKKNMLFS GTNIAAGKAL GIVATTGVGT EIGKIRDQMA 240
ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 300
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 360
MSVCKMFIID KVDGDICLLN EFSITGSTYA PEGEVLKNDK PVRPGQYDGL VELATICALC 420
NDSSLDFNEA KGVYEKVGEA TETALTTLVE KMNVFNTDVR SLSKVERANA CNSVIRQLMK 480
KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 540
VKEKIMAVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SARFLEYETD LTFVGVVGML 600
DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFGENEEVAD RAYTGREFDD 660
LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 720
GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 780
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI 840
GGYVGAATVG AAAWWFLYAE DGPHVNYSQL THFMQCTEDN THFEGIDCEV FEAPEPMTMA 900
LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 960
ALDLTQWLMV LKISLPVIGL DEILKFVARN YLEDPEDERR K 1001 
Gene Ontology
 GO:0034704; C:calcium channel complex; IC:BHF-UCL.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
 GO:0031673; C:H zone; IDA:UniProtKB.
 GO:0031674; C:I band; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0031095; C:platelet dense tubular network membrane; TAS:Reactome.
 GO:0016529; C:sarcoplasmic reticulum; ISS:UniProtKB.
 GO:0033017; C:sarcoplasmic reticulum membrane; TAS:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IMP:UniProtKB.
 GO:0005388; F:calcium-transporting ATPase activity; IDA:UniProtKB.
 GO:0008637; P:apoptotic mitochondrial changes; IMP:BHF-UCL.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0070509; P:calcium ion import; IMP:BHF-UCL.
 GO:0032470; P:elevation of endoplasmic reticulum calcium ion concentration; IMP:BHF-UCL.
 GO:0051561; P:elevation of mitochondrial calcium ion concentration; IMP:BHF-UCL.
 GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:BHF-UCL.
 GO:0051659; P:maintenance of mitochondrion location; IMP:BHF-UCL.
 GO:0045988; P:negative regulation of striated muscle contraction; IMP:UniProtKB.
 GO:0031448; P:positive regulation of fast-twitch skeletal muscle fiber contraction; IDA:UniProtKB.
 GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IMP:BHF-UCL.
 GO:0090076; P:relaxation of skeletal muscle; IDA:BHF-UCL. 
Interpro
 IPR005782; ATPase_P-typ_Ca-transp_IIA.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.
 PR00120; HATPASE.