CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030269
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myo18a protein 
Protein Synonyms/Alias
 Unconventional myosin-XVIIIa 
Gene Name
 Myo18a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
469APAVYSEKVMHMFKGubiquitination[1]
976LLQDSQKKIISNLFLubiquitination[1]
1045DALIDTIKRSKMHFVacetylation[2]
1843ETRLEFEKTQVKRLEacetylation[3]
1984KSWLSKNKGPSKAPSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2047 AA 
Protein Sequence
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR SSKRESKTRL 60
EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 120
AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLMQHP 180
GLGIPRPGPR SRVPELVTKR FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM 240
LDRAPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG 300
DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADLDPEAAS PAYSQAKTEE QIAAEEAWYE 360
TEKVWLVHRD GFSLASQLKS EELSLPEGKA RVKLDHDGAI LDVDEDDIEK ANAPSCDRLE 420
DLASLVYLNE SSVLHTLRQR YGASLLHTYA GPSLLVLSTR GAPAVYSEKV MHMFKGCRRE 480
DMAPHIYAVA QTAYRAMLMS RQDQSIVLLG SSGSGKTTSF QHLVQYLATI AGTSGTKVFS 540
VEKWQALSTL LEAFGNSPTI MNGSATRFSQ ILSLDFDQAG QVASASIQTM LLEKLRVARR 600
PASEATFNVF YYLLACGDAT LRTELHLNHL AENNVFGIVP LSKPEEKQKA AQQFSKLQAA 660
MKVLAISPEE QKTCWLILAS IYHLGAAGAT KEAAEAGRKQ FARHEWAQKA AYLLGCSLEE 720
LSSAIFKHQL KGGTLQRSTS FRQGPEESGL GEGTKLSALE CLEGMASGLY SELFTLLISL 780
VNRALKSSQH SLCSMMIVDT PGFQNPEWGG SARGASFEEL CHNYAQDRLQ RLFHERTFLQ 840
ELERYKEDNI ELAFDDLEPV ADDSVAAVDQ ASHLVRSLAH ADEARGLLWL LEEEALVPGA 900
TEDALLDRLF SYYGPQEGDK KGQSPLLRSS KPRHFLLGHS HGTNWVEYNV AGWLNYTKQN 960
PATQNAPRLL QDSQKKIISN LFLGRAGSAT VLSGSIAGLE GGSQLALRRA TSMRKTFTTG 1020
MAAVKKKSLC IQIKLQVDAL IDTIKRSKMH FVHCFLPVAE GWPGEPRSAS SRRVSSSSEL 1080
DLPPGDPCEA GLLQLDVSLL RAQLRGSRLL DAMRMYRQGY PDHMVFSEFR RRFDVLAPHL 1140
TKKHGRNYIV VDEKRAVEEL LESLDLEKSS CCLGLSRVFF RAGTLARLEE QRDEQTSRHL 1200
TLFQAACRGY LARQHFKKRK IQDLAIRCVQ KNIKKNKGVK DWPWWKLFTT VRPLIQVQLS 1260
EEQIRNKDEE IQQLRSKLEK VEKERNELRL SSDRLETRIS ELTSELTDER NTGESASQLL 1320
DAETAERLRT EKEMKELQTQ YDALKKQMEV MEMEVMEARL IRAAEINGEV DDDDAGGEWR 1380
LKYERAVREV DFTKKRLQQE LEDKMEVEQQ SRRQLERRLG DLQADSDESQ RALQQLKKKC 1440
QRLTAELQDT KLHLEGQQVR NHELEKKQRR FDSELSQAHE ETQREKLQRE KLQREKDMLL 1500
AEAFSLKQQM EEKDLDIAGF TQKVVSLEAE LQDISSQESK DEASLAKVKK QLRDLEAKVK 1560
DQEEELDEQA GSIQMLEQAK LRLEMEMERM RQTHSKEMES RDEEVEEARQ SCQKKLKQME 1620
VQLEEEYEDK QKALREKREL ESKLSTLSDQ VNQRDFESEK RLRKDLKRTK ALLADAQIML 1680
DHLKNNAPSK REIAQLKNQL EESEFTCAAA VKARKAMEVE MEDLHLQIDD IAKAKTALEE 1740
QLSRLQREKN EIQNRLEEDQ EDMNELMKKH KAAVAQASRD MAQMNDLQAQ IEESNKEKQE 1800
LQEKLQALQS QVEFLEQSMV DKSLVSRQEA KIRELETRLE FEKTQVKRLE NLASRLKETM 1860
EKLTEERDQR AAAENREKEQ NKRLQRQLRD TKEEMSELAR KEAEASRKKH ELEMDLESLE 1920
AANQSLQADL KLAFKRIGDL QAAIEDEMES DENEDLINSE GDSDVDSELE DRVDGVKSWL 1980
SKNKGPSKAP SDDGSLKSSS PTSHWKPLAP DPSDDEHDPV DSISRPRFSH SYLSDSDTEA 2040
KLTETSA 2047 
Gene Ontology
 GO:0005856; C:cytoskeleton; IDA:MGI.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ. 
Pfam
 PF00063; Myosin_head
 PF01576; Myosin_tail_1
 PF00595; PDZ 
SMART
 SM00015; IQ
 SM00242; MYSc
 SM00228; PDZ 
PROSITE
 PS50096; IQ
 PS50106; PDZ 
PRINTS
 PR00193; MYOSINHEAVY.