UniProt Accession

 E9Q1G8_MOUSE; E9Q1G8 

Genbank Protein ID

 CT025561 

Genbank Nucleotide ID

  

Protein Name

 Septin-7 

Protein Synonyms/Alias

  

Gene Name

 Sept7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
97	TVQVEQSKVLIKEGG	acetylation	[1]
97	TVQVEQSKVLIKEGG	ubiquitination	[2]
186	FMKRLHEKVNIIPLI	acetylation	[1]
186	FMKRLHEKVNIIPLI	ubiquitination	[2]
195	NIIPLIAKADTLTPE	acetylation	[1]
208	PEECQQFKKQIMKEI	ubiquitination	[2]
213	QFKKQIMKEIQEHKI	ubiquitination	[2]
221	EIQEHKIKIYEFPET	acetylation	[1]
235	TDDEEENKLVKKIKD	acetylation	[3]
235	TDDEEENKLVKKIKD	ubiquitination	[2]
238	EEENKLVKKIKDRLP	ubiquitination	[2]
260	TIIEVNGKRVRGRQY	ubiquitination	[2]
298	RTHMQDLKDVTNNVH	ubiquitination	[2]
313	YENYRSRKLAAVTYN	ubiquitination	[2]
326	YNGVDNNKNKGQLTK	ubiquitination	[2]
333	KNKGQLTKSPLAQME	ubiquitination	[2]
352	EHVAKMKKMEMEMEQ	ubiquitination	[2]
373	KEKVQKLKDSEAELQ	acetylation	[4]
373	KEKVQKLKDSEAELQ	ubiquitination	[2]
395	KNLEAQHKELEEKRR	ubiquitination	[2]
408	RRQFEEEKANWEAQQ	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 437 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IDA:MGI.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:InterPro.
 GO:0051291; P:protein heterooligomerization; IEA:Compara. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin.
 IPR008115; Septin7. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS

 PR01742; SEPTIN7.