UniProt Accession

 H2AV_DROME; P08985; A0ANX7; A0ANX8; A0ANY0; A0ANY3; C0MJB2; C0MJB9; Q26252; Q540X2; Q9VBB1 

Genbank Protein ID

 X07485; X15549; AM294365; AM294366; AM294367; AM294368; AM294369; AM294370; AM294371; AM294372; FM245434; FM245435; FM245436; FM245437; FM245438; FM245439; FM245440; FM245441; FM245442; FM245443; FM245444; FM245445; AE014297; AY118910; S42733 

Genbank Nucleotide ID

 CAA30370.1; CAA33555.1; CAL26295.1; CAL26296.1; CAL26297.1; CAL26298.1; CAL26299.1; CAL26300.1; CAL26301.1; CAL26302.1; CAR93360.1; CAR93361.1; CAR93362.1; CAR93363.1; CAR93364.1; CAR93365.1; CAR93366.1; CAR93367.1; CAR93368.1; CAR93369.1; CAR93370.1; CAR93371.1; AAF56631.1; AAM50770.1; AAB22897.1 

Protein Name

 Histone H2A.v 

Protein Synonyms/Alias

 H2A.F/Z; H2A.Z 

Gene Name

 His2Av 

Gene Synonyms/Alias

 H2AvD; His2AvD; CG5499 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
5	***MAGGKAGKDSGK	acetylation	[1]
8	MAGGKAGKDSGKAKA	acetylation	[1]
12	KAGKDSGKAKAKAVS	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation. Also involved in DNA double strand break (DSB) repair. Essential for early development. 

Sequence Annotation

 REGION 93 103 Essential for function in development.
 MOTIF 138 139 [ST]-Q motif.
 MOD_RES 5 5 N6-acetyllysine.
 MOD_RES 138 138 Phosphoserine.
 CROSSLNK 121 121 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Complete proteome; Developmental protein; DNA damage; DNA repair; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 141 AA 

Protein Sequence

Gene Ontology

 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0000786; C:nucleosome; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0005700; C:polytene chromosome; IDA:FlyBase.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0071168; P:protein localization to chromatin; IDA:FlyBase.
 GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.