CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016173
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein PAT1 homolog 1 
Protein Synonyms/Alias
 PAT1-like protein 1; Protein PAT1 homolog b; Pat1b; hPat1b 
Gene Name
 PATL1 
Gene Synonyms/Alias
 OK/KNS-cl.5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
299PLAAMNPKLLQGRVGubiquitination[1]
495SSVNNPRKMIDAVVTubiquitination[1]
625RNLPFLIKKDAQDEVacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). 
Sequence Annotation
 REGION 1 397 Involved in nuclear foci localization.
 REGION 1 84 Region A; interaction with DDX6/RCK.
 REGION 85 388 Region N; interaction with decapping
 REGION 223 397 Involved in RNA-binding.
 REGION 389 448 Region H.
 REGION 398 770 Involved in nuclear spleckles
 REGION 449 770 Region C.
 MOTIF 86 95 Nuclear export signal.
 MOD_RES 177 177 Phosphoserine.
 MOD_RES 178 178 Phosphothreonine (By similarity).
 MOD_RES 179 179 Phosphoserine.
 MOD_RES 184 184 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 770 AA 
Protein Sequence
MFRYESLEDC PLDEDEDAFQ GLGEEDEEID QFNDDTFGSG AVDDDWQEAH ERLAELEEKL 60
PVAVNEQTGN GERDEMDLLG DHEENLAERL SKMVIENELE DPAIMRAVQT RPVLQPQPGS 120
LNSSIWDGSE VLRRIRGPLL AQEMPTVSVL EYALPQRPPQ GPEDDRDLSE RALPRRSTSP 180
IIGSPPVRAV PIGTPPKQMA VPSFTQQILC PKPVHVRPPM PPRYPAPYGE RMSPNQLCSV 240
PNSSLLGHPF PPSVPPVLSP LQRAQLLGGA QLQPGRMSPS QFARVPGFVG SPLAAMNPKL 300
LQGRVGQMLP PAPGFRAFFS APPSATPPPQ QHPPGPGPHL QNLRSQAPMF RPDTTHLHPQ 360
HRRLLHQRQQ QNRSQHRNLN GAGDRGSHRS SHQDHLRKDP YANLMLQREK DWVSKIQMMQ 420
LQSTDPYLDD FYYQNYFEKL EKLSAAEEIQ GDGPKKERTK LITPQVAKLE HAYKPVQFEG 480
SLGKLTVSSV NNPRKMIDAV VTSRSEDDET KEKQVRDKRR KTLVIIEKTY SLLLDVEDYE 540
RRYLLSLEEE RPALMDDRKH KICSMYDNLR GKLPGQERPS DDHFVQIMCI RKGKRMVARI 600
LPFLSTEQAA DILMTTARNL PFLIKKDAQD EVLPCLLSPF SLLLYHLPSV SITSLLRQLM 660
NLPQSAATPA LSNPHLTAVL QNKFGLSLLL ILLSRGEDLQ SSDPATESTQ NNQWTEVMFM 720
ATRELLRIPQ AALAKPISIP TNLVSLFSRY VDRQKLNLLE TKLQLVQGIR 770 
Gene Ontology
 GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
 GO:0034046; F:poly(G) RNA binding; IDA:MGI.
 GO:0008266; F:poly(U) RNA binding; IDA:MGI.
 GO:0033962; P:cytoplasmic mRNA processing body assembly; IDA:UniProtKB.
 GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IDA:UniProtKB.
 GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome. 
Interpro
 IPR019167; Topo_II-assoc_PAT1. 
Pfam
 PF09770; PAT1 
SMART
  
PROSITE
  
PRINTS