CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040884
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase D 
Protein Synonyms/Alias
  
Gene Name
 PRKD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
300QYCKKLLKGLFRQGLubiquitination[1]
745FARIIGEKSFRRSVVubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 920 AA 
Protein Sequence
MSAPPVLRPP SPLLPVAAAA AAAAAALVPG SGPGPAPFLA PVAAPVGGIS FHLQIGLSRE 60
PVLLLQDSSG DYSLAHVREM ACSIVDQKFP ECGFYGMYDK ILLFRHDPTS ENILQLVKAA 120
SDIQEGDLIE VVLSASATFE DFQIRPHALF VHSYRAPAFC DHCGEMLWGL VRQGLKCEGC 180
GLNYHKRCAF KIPNNCSGVR RRRLSNVSLT GVSTIRTSSA ELSTSAPDEP LLSPVSPGFE 240
QKSPSESFIG REKRSNSQSY IGRPIHLDKI LMSKVKVPHT FVIHSYTRPT VCQYCKKLLK 300
GLFRQGLQCK DCRFNCHKRC APKVPNNCLG EVTINGDLLS PGAESDVVME EGSDDNDSER 360
NSGLMDDMEE AMVQDAEMAM AECQNDSGEM QDPDPDHEDA NRTISPSTSN NIPLMRVVQS 420
VKHTKRKSST VMKEGWMVHY TSKDTLRKRH YWRLDSKCIT LFQNDTGSRY YKEIPLSEIL 480
SLEPVKTSAL IPNGANPHCF EITTANVVYY VGENVVNPSS PSPNNSVLTS GVGADVARMW 540
EIAIQHALMP VIPKGSSVGT GTNLHRDISV SISVSNCQIQ ENVDISTVYQ IFPDEVLGSG 600
QFGIVYGGKH RKTGRDVAIK IIDKLRFPTK QESQLRNEVA ILQNLHHPGV VNLECMFETP 660
ERVFVVMEKL HGDMLEMILS SEKGRLPEHI TKFLITQILV ALRHLHFKNI VHCDLKPENV 720
LLASADPFPQ VKLCDFGFAR IIGEKSFRRS VVGTPAYLAP EVLRNKGYNR SLDMWSVGVI 780
IYVSLSGTFP FNEDEDIHDQ IQNAAFMYPP NPWKEISHEA IDLINNLLQV KMRKRYSVDK 840
TLSHPWLQDY QTWLDLRELE CKIGERYITH ESDDLRWEKY AGEQGLQYPT HLINPSASHS 900
DTPETEETEM KALGERVSIL 920 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004697; F:protein kinase C activity; IEA:EC.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR020454; DAG/PE-bd.
 IPR011009; Kinase-like_dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR015727; Protein_Kinase_C_mu-related.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00130; C1_1
 PF00169; PH
 PF00069; Pkinase 
SMART
 SM00109; C1
 SM00233; PH
 SM00220; S_TKc 
PROSITE
 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00008; DAGPEDOMAIN.