UniProt Accession

 PSF3_HUMAN; Q9BRX5; B2RDP3; E9PB21; Q9H870 

Genbank Protein ID

 AK023974; AK315622; CR457283; AC009107; AC009118; AC084063; CH471092; CH471092; BC005879; BC014437 

Genbank Nucleotide ID

 BAB14747.1; BAG37990.1; CAG33564.1; EAW82973.1; EAW82976.1; AAH05879.1; AAH14437.1 

Protein Name

 DNA replication complex GINS protein PSF3 

Protein Synonyms/Alias

 GINS complex subunit 3 

Gene Name

 GINS3 

Gene Synonyms/Alias

 PSF3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	DILMSHEKLPVRTET	ubiquitination	[1]
65	NAVPQGSKLELPLWL	ubiquitination	[2]
74	ELPLWLAKGLFDNKR	ubiquitination	[2]
80	AKGLFDNKRRILSVE	ubiquitination	[3]
90	ILSVELPKIYQEGWR	ubiquitination	[2, 4]
181	GLFQTGQKGLNDFQC	ubiquitination	[1, 2, 3]
191	NDFQCWEKGQASQIT	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. 

Sequence Annotation

 REGION 1 16 Not essential for folding and stability  

Keyword

 3D-structure; Alternative splicing; Complete proteome; DNA replication; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 

Interpro

 IPR021151; GINS_complex.
 IPR010492; GINS_Psf3. 

Pfam

 PF05916; Sld5 

SMART

  

PROSITE

  

PRINTS