CPLM-009006

Genbank Nucleotide ID

BH3-interacting domain death agonist

Protein Synonyms/Alias

p22 BID; BID; BH3-interacting domain death agonist p15; p15 BID; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID

Homo sapiens (Human)

Position	Peptide	Type	References
158	LALLLAKKVASHTPS	ubiquitination	[1, 2, 3]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]

Functional Description

The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

MOTIF 86 100 BH3.
MOD_RES 54 54 Phosphotyrosine.
MOD_RES 78 78 Phosphoserine.

3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0032592; C:integral to mitochondrial membrane; IEA:Compara.
GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO:0005123; F:death receptor binding; TAS:ProtInc.
GO:0007420; P:brain development; IEA:Compara.
GO:0090150; P:establishment of protein localization to membrane; IDA:BHF-UCL.
GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; TAS:ProtInc.
GO:0034349; P:glial cell apoptotic process; IEA:Compara.
GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:Reactome.
GO:0051402; P:neuron apoptotic process; TAS:HGNC.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; TAS:Reactome.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization; TAS:Reactome.
GO:0032464; P:positive regulation of protein homooligomerization; IDA:BHF-UCL.
GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
GO:0051260; P:protein homooligomerization; IEA:Compara.
GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
GO:0042127; P:regulation of cell proliferation; IEA:Compara.
GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:Compara.
GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Compara.
GO:0001836; P:release of cytochrome c from mitochondria; IDA:HGNC.
GO:0032355; P:response to estradiol stimulus; IEA:Compara.

IPR020728; Bcl2_BH3_motif_CS.
IPR010479; BID.