UniProt Accession

 APOE_RAT; P02650 

Genbank Protein ID

 X04979; J02582; S76779; BC086581 

Genbank Nucleotide ID

 CAA28650.1; AAA40755.1; AAC60703.1; AAH86581.1 

Protein Name

 Apolipoprotein E 

Protein Synonyms/Alias

 Apo-E 

Gene Name

 Apoe 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
105	ETRARLAKEVQAAQA	ubiquitination	[1]
252	QMEEVRSKMEEQTQQ	acetylation	[2]
252	QMEEVRSKMEEQTQQ	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. 

Sequence Annotation

 REPEAT 72 93 1.
 REPEAT 94 115 2.
 REPEAT 116 137 3.
 REPEAT 138 159 4.
 REPEAT 160 181 5.
 REPEAT 182 203 6.
 REPEAT 204 225 7.
 REPEAT 226 247 8.
 REGION 72 247 8 X 22 AA approximate tandem repeats.
 REGION 150 160 LDL receptor binding (Potential).
 REGION 154 157 Heparin-binding (By similarity).
 REGION 221 228 Heparin-binding (By similarity).  

Keyword

 Chylomicron; Complete proteome; Direct protein sequencing; HDL; Heparin-binding; Lipid transport; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Transport; VLDL. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0031232; C:extrinsic to external side of plasma membrane; IDA:RGD.
 GO:0005794; C:Golgi apparatus; IDA:RGD.
 GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0034363; C:intermediate-density lipoprotein particle; IEA:Compara.
 GO:0005770; C:late endosome; IDA:RGD.
 GO:0034362; C:low-density lipoprotein particle; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0016209; F:antioxidant activity; IEA:Compara.
 GO:0001540; F:beta-amyloid binding; ISS:UniProtKB.
 GO:0017127; F:cholesterol transporter activity; IEA:Compara.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0046848; F:hydroxyapatite binding; IDA:RGD.
 GO:0005319; F:lipid transporter activity; IDA:RGD.
 GO:0071813; F:lipoprotein particle binding; IEA:Compara.
 GO:0046911; F:metal chelating activity; IEA:Compara.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Compara.
 GO:0005543; F:phospholipid binding; IDA:RGD.
 GO:0007568; P:aging; IDA:RGD.
 GO:0048844; P:artery morphogenesis; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0071397; P:cellular response to cholesterol; IEP:RGD.
 GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
 GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
 GO:0019934; P:cGMP-mediated signaling; IEA:Compara.
 GO:0006707; P:cholesterol catabolic process; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0034382; P:chylomicron remnant clearance; IEA:Compara.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0034380; P:high-density lipoprotein particle assembly; IEA:Compara.
 GO:0034384; P:high-density lipoprotein particle clearance; IEA:Compara.
 GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0042158; P:lipoprotein biosynthetic process; IEA:Compara.
 GO:0042159; P:lipoprotein catabolic process; IEA:Compara.
 GO:0042157; P:lipoprotein metabolic process; IDA:RGD.
 GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0051651; P:maintenance of location in cell; IEA:Compara.
 GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IEA:Compara.
 GO:0045541; P:negative regulation of cholesterol biosynthetic process; IEA:Compara.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0043407; P:negative regulation of MAP kinase activity; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IDA:RGD.
 GO:0010544; P:negative regulation of platelet activation; IEA:Compara.
 GO:0007263; P:nitric oxide mediated signal transduction; IEA:Compara.
 GO:0048709; P:oligodendrocyte differentiation; IEP:RGD.
 GO:0014012; P:peripheral nervous system axon regeneration; IEP:RGD.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0045773; P:positive regulation of axon extension; IDA:RGD.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Compara.
 GO:0010875; P:positive regulation of cholesterol efflux; IEA:Compara.
 GO:0010873; P:positive regulation of cholesterol esterification; IEA:Compara.
 GO:0032805; P:positive regulation of low-density lipoprotein particle receptor catabolic process; IEA:Compara.
 GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Compara.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0006898; P:receptor-mediated endocytosis; IEA:Compara.
 GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Compara.
 GO:0010468; P:regulation of gene expression; IEA:Compara.
 GO:0002021; P:response to dietary excess; IEA:Compara.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0032868; P:response to insulin stimulus; IEP:RGD.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEP:RGD.
 GO:0043691; P:reverse cholesterol transport; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara.
 GO:0042311; P:vasodilation; IEA:Compara.
 GO:0034447; P:very-low-density lipoprotein particle clearance; IEA:Compara.
 GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:Compara. 

Interpro

 IPR013326; ApoA.
 IPR000074; ApoA1_A4_E. 

Pfam

 PF01442; Apolipoprotein 

SMART

  

PROSITE

  

PRINTS