CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022291
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uridine-cytidine kinase-like 1 
Protein Synonyms/Alias
  
Gene Name
 UCKL1 
Gene Synonyms/Alias
 URKL1; F538 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
261KQYNKFVKPSFDQYIubiquitination[1, 2]
328PRTLSVLKSTPQVRGubiquitination[2]
392AGKCYAGKQITGVSIubiquitination[2]
510IITTAVDKRVNDLFRubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 May contribute to UTP accumulation needed for blast transformation and proliferation. 
Sequence Annotation
 NP_BIND 105 112 ATP (Potential).
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 107 107 Phosphoserine (By similarity).
 MOD_RES 539 539 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Host-virus interaction; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transferase; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 548 AA 
Protein Sequence
MAAPPARADA DPSPTSPPTA RDTPGRQAEK SETACEDRSN AESLDRLLPP VGTGRSPRKR 60
TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA IGLGGGSASG KTTVARMIIE 120
ALDVPWVVLL SMDSFYKVLT EQQQEQAAHN NFNFDHPDAF DFDLIISTLK KLKQGKSVKV 180
PIYDFTTHSR KKDWKTLYGA NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR 240
DISERGRDIE GVIKQYNKFV KPSFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL 300
EERELSVRAA LASAHQCHPL PRTLSVLKST PQVRGMHTII RDKETSRDEF IFYSKRLMRL 360
LIEHALSFLP FQDCVVQTPQ GQDYAGKCYA GKQITGVSIL RAGETMEPAL RAVCKDVRIG 420
TILIQTNQLT GEPELHYLRL PKDISDDHVI LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF 480
LLSLLMAEMG VHSVAYAFPR VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD 540
EEEVAYTG 548 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0004849; F:uridine kinase activity; IEA:EC.
 GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
 GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR006083; PRK/URK.
 IPR000764; Uridine_kinase. 
Pfam
 PF00485; PRK 
SMART
  
PROSITE
  
PRINTS
 PR00988; URIDINKINASE.