CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029826
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein unc-13 homolog B 
Protein Synonyms/Alias
  
Gene Name
 UNC13B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19KFQGSPDKFNTYVTLubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1622 AA 
Protein Sequence
MSLLCVRVKR AKFQGSPDKF NTYVTLKVQN VKSTTVAVRG DQPSWEQDFM FEISRLDLGL 60
SVEVWNKGLI WDTMVGTVWI ALKTIRQSDE EGPGEWSTLE AETLMKDDEI CGTRNPTPHK 120
ILLDTRFELP FDIPEEEARY WTYKWEQINA LGADNEYSSQ EESQRKPLPT AAAQCCHWTY 180
LGWGEQQTFE DPDSAVDDRD SDYRSETSNS FPPPYHTASQ PNASVHQFPV PVRSPQQLLL 240
QGSSRDSCND SMQSYDLDYP ERRAISPTSS SRYGSSCNVS QGSSQLSELD QYHEQDDDHR 300
ETDSIHSCHS SHSLSRDGQA GFGEQEKPLE VTGQAEKEAA CEPKEMKEDA TTHPPPDLVL 360
QKDHFLGPQE SFPEENASSP FTQARAHWIR AVTKVRLQLQ EIPDDGDPSL PQWLPEGPAG 420
GLYGIDSMPD LRRKKPLPLV SDLSLVQSRK AGITSAMATR TSLKDEELKS HVYKKTLQAL 480
IYPISCTTPH NFEVWTATTP TYCYECEGLL WGIARQGMRC SECGVKCHEK CQDLLNADCL 540
QRAAEKSCKH GAEDRTQNII MAMKDRMKIR ERNKPEIFEV IRDVFTVNKA AHVQQMKTVK 600
QSVLDGTSKW SAKITITVVC AQGLQAKDKT GSSDPYVTVQ VSKTKKRTKT IFGNLNPVWE 660
EKFHFECHNS SDRIKVRVWD EDDDIKSRVK QRLKRESDDF LGQTIIEVRT LSGEMDVWYN 720
LEKRTDKSAV SGAIRLQISV EIKGEEKVAP YHVQYTCLHE NLFHYLTDIQ GSGGVRIPEA 780
RGDDAWKVYF DETAQEIVDE FAMRYGIESI YQAMTHFACL SSKYMCPGVP AVMSTLLANI 840
NAYYAHTTAS TNVSASDRFA ASNFGKERFV KLLDQLHNSL RIDLSTYRNN FPAGSPERLQ 900
DLKSTVDLLT SITFFRMKVQ ELQSPPRASQ VVKDCVKACL NSTYEYIFNN CHDLYSRQYQ 960
LKQELPPEEQ GPSIRNLDFW PKLITLIVSI IEEDKNSYTP VLNQFPQELN VGKVSAEVMW 1020
HLFAQDMKYA LEEHEKDHLC KSADYMNLHF KVKWLHNEYV RDLPVLQGQV PEYPAWFEQF 1080
VLQWLDENED VSLEFLRGAL ERDKKDGFQQ TSEHALFSCS VVDVFTQLNQ SFEIIRKLEC 1140
PDPSILAHYM RRFAKTIGKV LMQYADILSK DFPAYCTKEK LPCILMNNVQ QLRVQLEKMF 1200
EAMGGKELDL EAADSLKELQ VKLNTVLDEL SMVFGNSFQV RIDECVRQMA DILGQVRGTG 1260
NASPDARASA AQDADSVLRP LMDFLDGNLT LFATVCEKTV LKRVLKELWR VVMNTMERMI 1320
VLPPLTDQTG TQLIFTAAKE LSHLSKLKDH MVREETRNLT PKQCAVLDLA LDTIKQYFHA 1380
GGNGLKKTFL EKSPDLQSLR YALSLYTQTT DTLIKTFVRS QTTQVHDGKG IRFTANEDIR 1440
PEKGSGVDDP VGEVSIQVDL FTHPGTGEHK VTVKVVAAND LKWQTAGMFR PFVEVTMVGP 1500
HQSDKKRKFT TKSKSNNWAP KYNETFHFLL GNEEGPESYE LQICVKDYCF AREDRVLGLA 1560
VMPLRDVTAK GSCACWCPLG RKIHMDETGL TILRILSQRS NDEVAREFVK LKSESRSTEE 1620
GS 1622 
Gene Ontology
 GO:0019992; F:diacylglycerol binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007268; P:synaptic transmission; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR010439; Ca-dep_secretion_activator.
 IPR014770; Munc13_1.
 IPR014772; Munc13_dom-2.
 IPR019558; Munc13_subgr_dom-2.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR027080; Unc-13. 
Pfam
 PF00130; C1_1
 PF00168; C2
 PF06292; DUF1041
 PF10540; Membr_traf_MHD 
SMART
 SM00109; C1
 SM00239; C2 
PROSITE
 PS50004; C2
 PS51258; MHD1
 PS51259; MHD2
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00360; C2DOMAIN.