UniProt Accession

 KLF6_HUMAN; Q99612; B2RE86; B4DDN0; D3DRR1; F5H3M5; Q5VUT7; Q5VUT8; Q9BT79 

Genbank Protein ID

 U44975; AF001461; AB017493; AF284036; BT006778; AL513303; AL450322; AK293259; AK316596; AL513303; AL450322; AL450322; AL513303; AL450322; AL513303; CH471072; CH471072; BC000311 

Genbank Nucleotide ID

 AAC23699.1; AAC39929.1; BAA33050.1; AAM73548.1; AAP35424.1; CAH74049.1; CAH74049.1; BAG56791.1; BAG38183.1; CAH74050.1; CAH74050.1; CAH71010.1; CAH71010.1; CAH71011.1; CAH71011.1; EAW86477.1; EAW86479.1; AAH00311.1 

Protein Name

 Krueppel-like factor 6 

Protein Synonyms/Alias

 B-cell-derived protein 1; Core promoter element-binding protein; GC-rich sites-binding factor GBF; Proto-oncogene BCD1; Suppressor of tumorigenicity 12 protein; Transcription factor Zf9 

Gene Name

 KLF6 

Gene Synonyms/Alias

 BCD1; COPEB; CPBP; ST12 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	SQEDLWTKIILAREK	ubiquitination	[1, 2]
209	CHFNGCRKVYTKSSH	acetylation	[3]
213	GCRKVYTKSSHLKAH	acetylation	[3]
218	YTKSSHLKAHQRTHT	acetylation	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation.
 Li D, Yea S, Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ, Friedman SL.
 Cancer Res. 2005 Oct 15;65(20):9216-25. [PMID: 16230382] 

Functional Description

 Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. 

Sequence Annotation

 ZN_FING 200 224 C2H2-type 1.
 ZN_FING 230 254 C2H2-type 2.
 ZN_FING 260 282 C2H2-type 3.  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; TAS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030183; P:B cell differentiation; NAS:UniProtKB.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; TAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS