UniProt Accession

 CCDB1_HUMAN; O95273; A8K3Q0; A8K3U2; Q6ZQN9; Q7Z519; Q8NBS7; Q8NBY2; Q9NS19; Q9NYH3; Q9UHX9 

Genbank Protein ID

 AF082569; AF132034; AF246144; AF087852; AF113535; CR450331; AK075296; AK128849; AK290665; AK290707; AK075146; CH471125; CH471125; BC009689 

Genbank Nucleotide ID

 AAD11777.1; AAF77613.1; AAF67182.1; AAP97163.1; AAF14872.1; CAG29327.1; BAC11530.1; BAC87645.1; BAF83354.1; BAF83396.1; BAC11433.1; EAW92588.1; EAW92590.1; AAH09689.1 

Protein Name

 Cyclin-D1-binding protein 1 

Protein Synonyms/Alias

 Grap2 and cyclin-D-interacting protein; Human homolog of Maid 

Gene Name

 CCNDBP1 

Gene Synonyms/Alias

 DIP1; GCIP; HHM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	PSPQETQKFCEQVHA	ubiquitination	[1]
170	PQIPRDNKAAALLML	ubiquitination	[2]
179	AALLMLTKNVDFVKD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription. 

Sequence Annotation

 REGION 1 208 Required for interaction with CCND1.
 REGION 1 190 Interaction with RPLP0.
 REGION 1 184 Interaction with TCF3.
 REGION 150 360 Interaction with TCF3.
 REGION 240 360 Interaction with RPLP0.  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051726; P:regulation of cell cycle; IEA:InterPro. 

Interpro

 IPR026907; CCNDBP1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS