| Tag | Content |
|---|
| CPLM ID | CPLM-008579 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Telomere length regulation protein TEL2 |
Protein Synonyms/Alias | |
Gene Name | TEL2 |
Gene Synonyms/Alias | YGR099W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 399 | NTQTDVGKDKITEVS | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats. |
Sequence Annotation | MOD_RES 417 417 Phosphoserine.
MOD_RES 419 419 Phosphoserine. |
Keyword | 3D-structure; Chromosome; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Telomere. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 688 AA |
Protein Sequence | MVLETLKQGL DSSQIHEALI QLDSYPREPV DLDASMVLIK FVIPVYPSLP ERSKVILRRL 60
ASKSFTFLCQ IVTFSRTISG RDGLQEIRIY QEILEDIISF EPGCLTFYLK ASTTSKADRD 120
SIKALFFGSK LFNVLANRID MAKYLGYLRL QWKFLLESNE TDPPGFLGEW LVSSFLLNPV 180
LAADMLLGEL FLLKESYFFS FQKIISASSL IDQKRLIAKF LLPYIQVIVT LENLNDVRKI 240
LRRFDLDKII SLSVLFEIQS LPLKEVIVRL MSNHSSTKFV SALVSKFADF TDEEVDTKTC 300
ELLVLFAVHN LNHSQREEIA HDERFLNGVT KHLGSNEREA RERAMFIAKL LSGGHLKYES 360
DFKINIPNVK FESNSDDKII DFQSLKNPSI CNTQTDVGKD KITEVSGHVQ SLTLDCSDSD 420
DEDENDEREI VKRIVFLKDL MKEYEKTGES RKAPLIPLLK QTVKLIRQKA DFQLEVGYYA 480
QGILSSIVCL NNEFDEPLFE QWRINALTSI LVVLPEKVNG AINILFNSEL SLQQRMSLLS 540
ALGLSARELR GLDDPTIVKP KFDFPTNRLP WDDQSHHNSR LVEVQESTSM IKKTKTVWKS 600
RKLGKDREKG TQNRFRKYAG LFFYPLAHGW LNGIDVGTYN QLFKSHYLTT LRIIYSCANP 660
VHDFESMTEL MNHIISSAIE EGISLNKG 688 |
Gene Ontology | GO:0070209; C:ASTRA complex; IDA:SGD. GO:0000783; C:nuclear telomere cap complex; IDA:SGD. GO:0042162; F:telomeric DNA binding; IDA:SGD. GO:0034502; P:protein localization to chromosome; IMP:SGD. GO:0007004; P:telomere maintenance via telomerase; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |