CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032911
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Programmed cell death 6-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 PDCD6IP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19TSEVDLAKPLVKFIQacetylation[1]
19TSEVDLAKPLVKFIQubiquitination[2, 3, 4, 5]
23DLAKPLVKFIQQTYPubiquitination[2, 3, 5]
48RAAEELSKLRRAAVGacetylation[6]
48RAAEELSKLRRAAVGubiquitination[3]
60AVGRPLDKHEGALETacetylation[5]
60AVGRPLDKHEGALETubiquitination[3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 153 AA 
Protein Sequence
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR RAAVGRPLDK 60
HEGALETLLR YYDQICSIEP KFPFSENQNL DNDEGLKIAA KHYQFASGAF LHIKETVLSA 120
LSREPTVDIS PDTVGTLSLI MLAQAQEVFF LKA 153 
Gene Ontology
  
Interpro
 IPR004328; BRO1_dom. 
Pfam
 PF03097; BRO1 
SMART
  
PROSITE
 PS51180; BRO1 
PRINTS