UniProt Accession

 DBHA_ECOLI; P0ACF0; P02342; Q2M8T7 

Genbank Protein ID

 X05994; U00006; U00096; AP009048; X54555; D12624 

Genbank Nucleotide ID

 CAA29412.1; AAC43098.1; AAC76974.1; BAE77319.1; CAA38426.1; BAA02149.1 

Protein Name

 DNA-binding protein HU-alpha 

Protein Synonyms/Alias

 HU-2; NS2 

Gene Name

 hupA 

Gene Synonyms/Alias

 b4000; JW3964 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
3	*****MNKTQLIDVI	acetylation	[1]
13	LIDVIAEKAELSKTQ	acetylation	[1, 2]
18	AEKAELSKTQAKAAL	acetylation	[1]
22	ELSKTQAKAALESTL	acetylation	[1]
51	LVGFGTFKVNHRAER	acetylation	[1]
67	GRNPQTGKEIKIAAA	acetylation	[1]
70	PQTGKEIKIAAANVP	acetylation	[1]
83	VPAFVSGKALKDAVK	acetylation	[1]
86	FVSGKALKDAVK***	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; DNA condensation; DNA-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 90 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:EcoliWiki.
 GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0006351; P:transcription, DNA-dependent; IDA:EcoCyc. 

Interpro

 IPR023630; DNA-bd_HU/IHF.
 IPR000119; Hist_DNA-bd_bac.
 IPR020816; Histone-like_DNA-bd_CS.
 IPR010992; IHF-like_DNA-bd_dom. 

Pfam

 PF00216; Bac_DNA_binding 

SMART

 SM00411; BHL 

PROSITE

 PS00045; HISTONE_LIKE 

PRINTS

 PR01727; DNABINDINGHU.