CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006220
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein YSC84 
Protein Synonyms/Alias
 LAS seventeen-binding protein 4; LAS17-binding protein 4 
Gene Name
 YSC84 
Gene Synonyms/Alias
 LSB4; YHR016C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
199MILSGRVKVPPAADPubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with LSB5. 
Sequence Annotation
 DOMAIN 409 468 SH3.
 MOD_RES 301 301 Phosphoserine.
 MOD_RES 311 311 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 468 AA 
Protein Sequence
MGINNPIPRS LKSETKKAAK VLRSFVKPNQ VFGADQVIPP YVLKRAKGLA IITVLKAGFL 60
FSGRAGSGVI VARLKDGTWS APSAIAMAGA GAGGMVGVEL TDFVFILNSE EAVRSFSEFG 120
TITLGGNVSV SAGPLGRSAE AAASASTGGV SAVFAYSKSK GLFAGVSVEG SAILERREAN 180
RKFYGDNCTS KMILSGRVKV PPAADPLLRI LESRAFNFTR HDHDDNASGD DFYDDGQYSD 240
NTSHYYDDIP DSFDSTDESS TRPNTRSSRR RGMSLGSRSR YDDDYDDDGY GRGRGYGDFD 300
SEDEDYDYGR SPNRNSSRNR GPQIDRGTKP RANTRWEDDL YDRDTEYSRP NHSGRDYDNT 360
RGNRRGYGRE RGYSLGHGPT HPSNMSNVDD LSHKMSKTGL GNESTATNSA TPTAVALYNF 420
AGEQPGDLAF KKGDVITILK KSDSQNDWWT GRTNGKEGIF PANYVRVS 468 
Gene Ontology
 GO:0030479; C:actin cortical patch; IDA:SGD.
 GO:0051015; F:actin filament binding; IDA:SGD.
 GO:0051666; P:actin cortical patch localization; IMP:SGD.
 GO:0051017; P:actin filament bundle assembly; IDA:SGD.
 GO:0006897; P:endocytosis; IGI:SGD. 
Interpro
 IPR001452; SH3_domain.
 IPR013315; Spectrin_alpha_SH3.
 IPR007461; Ysc84_actin-binding. 
Pfam
 PF04366; DUF500
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS50002; SH3 
PRINTS
 PR00452; SH3DOMAIN.
 PR01887; SPECTRNALPHA.