CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031591
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Multidrug resistance protein 1 
Protein Synonyms/Alias
  
Gene Name
 ABCB1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
178ILSSFTDKELLAYAKubiquitination[1]
185KELLAYAKAGAVAEEubiquitination[1]
207VIAFGGQKKELERYNubiquitination[1]
215KELERYNKNLEEAKRubiquitination[1, 2]
303GAAYEIFKIIDNKPSubiquitination[1, 2]
308IFKIIDNKPSIDSYSubiquitination[1]
316PSIDSYSKSGHKPDNubiquitination[1]
325GHKPDNIKGNLEFRNubiquitination[1]
451NAYDFIMKLPHKFDTubiquitination[1, 2]
455FIMKLPHKFDTLVGEubiquitination[1, 2]
511VVQVALDKARKGRTTubiquitination[1]
545DDGVIVEKGNHDELMubiquitination[1]
553GNHDELMKEKGIYFKubiquitination[1]
581ENAADESKSEIDALEubiquitination[1]
744VSWFDDPKNTTGALTubiquitination[1]
762ANDAAQVKGAIGSRLubiquitination[1]
851VSLTQEQKFEHMYAQubiquitination[1, 2]
1029FYDPLAGKVLLDGKEubiquitination[1, 2]
1100FIESLPNKYSTKVGDubiquitination[2]
1148ALDTESEKVVQEALDubiquitination[1]
1156VVQEALDKAREGRTCubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1216 AA 
Protein Sequence
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII 60
HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTSDVSKINE 120
GIGDKIGMFF QSMATFFTGF IVGFTRGWKL TLVILAISPV LGLSAAVWAK ILSSFTDKEL 180
LAYAKAGAVA EEVLAAIRTV IAFGGQKKEL ERYNKNLEEA KRIGIKKAIT ANISIGAAFL 240
LIYASYALAF WYGTTLVLSG EYSIGQVLTV FFSVLIGAFS VGQASPSIEA FANARGAAYE 300
IFKIIDNKPS IDSYSKSGHK PDNIKGNLEF RNVHFSYPSR KEVKILKGLN LKVQSGQTVA 360
LVGNSGCGKS TTVQLMQRLY DPTEGMVSVD GQDIRTINVR FLREIIGVVS QEPVLFATTI 420
AENIRYGREN VTMDEIEKAV KEANAYDFIM KLPHKFDTLV GERGAQLSGG QKQRIAIARA 480
LVRNPKILLL DEATSALDTE SEAVVQVALD KARKGRTTIV IAHRLSTVRN ADVIAGFDDG 540
VIVEKGNHDE LMKEKGIYFK LVTMQTAGNE VELENAADES KSEIDALEMS SNDSRSSLIR 600
KRSTRRSVRG SQAQDRKLST KEALDESIPP VSFWRIMKLN LTEWPYFVVG VFCAIINGGL 660
QPAFAIIFSK IIGVFTRIDD PETKRQNSNL FSLLFLALGI ISFITFFLQG FTFGKAGEIL 720
TKRLRYMVFR SMLRQDVSWF DDPKNTTGAL TTRLANDAAQ VKGAIGSRLA VITQNIANLG 780
TGIIISFIYG WQLTLLLLAI VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF 840
RTVVSLTQEQ KFEHMYAQSL QVPYRNSLRK AHIFGITFSF TQAMMYFSYA GCFRFGAYLV 900
AHKLMSFEDV LLVFSAVVFG AMAVGQVSSF APDYAKAKIS AAHIIMIIEK TPLIDSYSTE 960
GLMPNTLEGN VTFGEVVFNY PTRPDIPVLQ GLSLEVKKGQ TLALVGSSGC GKSTVVQLLE 1020
RFYDPLAGKV LLDGKEIKRL NVQWLRAHLG IVSQEPILFD CSIAENIAYG DNSRVVSQEE 1080
IVRAAKEANI HAFIESLPNK YSTKVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS 1140
ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VFQNGRVKEH GTHQQLLAQK 1200
GIYFSMVSVQ AGTKRQ 1216 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS