Tag | Content |
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CPLM ID | CPLM-002384 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA polymerase beta |
Protein Synonyms/Alias | |
Gene Name | Polb |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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72 | VGTKIAEKIDEFLAT | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. |
Sequence Annotation | REGION 183 192 DNA binding. ACT_SITE 72 72 Schiff-base intermediate with DNA (By METAL 101 101 Sodium; via carbonyl oxygen. METAL 103 103 Sodium; via carbonyl oxygen. METAL 106 106 Sodium; via carbonyl oxygen. METAL 190 190 Magnesium 1. METAL 190 190 Magnesium 2. METAL 192 192 Magnesium 1. METAL 192 192 Magnesium 2. METAL 256 256 Magnesium 2. MOD_RES 83 83 Omega-N-methylarginine; by PRMT6 (By MOD_RES 152 152 Omega-N-methylarginine; by PRMT6 (By CROSSLNK 41 41 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 61 61 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 81 81 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; DNA damage; DNA repair; DNA replication; DNA synthesis; DNA-binding; DNA-directed DNA polymerase; Isopeptide bond; Lyase; Magnesium; Metal-binding; Methylation; Nucleotidyltransferase; Nucleus; Reference proteome; Sodium; Transferase; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 335 AA |
Protein Sequence | MSKRKAPQET LNGGITDMLV ELANFEKNVS QAIHKYNAYR KAASVIAKYP HKIKSGAEAK 60 KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL TRVTGIGPSA ARKLVDEGIK 120 TLEDLRKNED KLNHHQRIGL KYFEDFEKRI PREEMLQMQD IVLNEVKKLD PEYIATVCGS 180 FRRGAESSGD MDVLLTHPNF TSESSKQPKL LHRVVEQLQK VRFITDTLSK GETKFMGVCQ 240 LPSENDENEY PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP 300 LGVTGVAGEP LPVDSEQDIF DYIQWRYREP KDRSE 335 |
Gene Ontology | |
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PROSITE | |
PRINTS | |