UniProt Accession

 PLCA_HUMAN; Q99943; A2BFI5; Q5BL03 

Genbank Protein ID

 U56417; U75971; Y09565; U89336; AL662884; AL662828; AL845464; BX284686; BX927239; CR933878; CR812478; CH471081; BC002402; BC003007; BC004310; BC090849 

Genbank Nucleotide ID

 AAB58775.1; AAB96378.1; CAA70758.1; AAB47493.1; CAI18347.1; CAI17430.1; CAI41807.1; CAM26221.1; CAQ06593.1; CAQ09622.1; CAQ10697.1; EAX03600.1; AAH02402.1; AAH03007.1; AAH04310.1; AAH90849.1 

Protein Name

 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha 

Protein Synonyms/Alias

 1-acylglycerol-3-phosphate O-acyltransferase 1; 1-AGP acyltransferase 1; 1-AGPAT 1; Lysophosphatidic acid acyltransferase alpha; LPAAT-alpha; Protein G15 

Gene Name

 AGPAT1 

Gene Synonyms/Alias

 G15 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	GRCVPIAKRELLWAG	ubiquitination	[1, 2]
191	NGSMLPFKRGAFHLA	ubiquitination	[1]
277	RGGGDYLKKPGGGG*	ubiquitination	[1]
278	GGGDYLKKPGGGG**	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. 

Sequence Annotation

 MOTIF 104 109 HXXXXD motif.  

Keyword

 Acyltransferase; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; IGI:BHF-UCL.
 GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0006654; P:phosphatidic acid biosynthetic process; IGI:BHF-UCL.
 GO:0031325; P:positive regulation of cellular metabolic process; TAS:Reactome.
 GO:0001819; P:positive regulation of cytokine production; IMP:BHF-UCL.
 GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IC:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 

Interpro

 IPR004552; AGP_acyltrans.
 IPR002123; Plipid/glycerol_acylTrfase. 

Pfam

 PF01553; Acyltransferase 

SMART

 SM00563; PlsC 

PROSITE

  

PRINTS