UniProt Accession

 HHEX_MOUSE; P43120; Q544N6; Q9CRV1; Q9R1X2 

Genbank Protein ID

 Z21524; AB017132; AF132550; AK014111; AK033664; BC057986 

Genbank Nucleotide ID

 CAA79729.1; BAA76714.1; AAF04349.1; BAB29163.1; BAC28416.1; AAH57986.1 

Protein Name

 Hematopoietically-expressed homeobox protein Hhex 

Protein Synonyms/Alias

 Homeobox protein HEX; mHex; Homeobox protein PRH 

Gene Name

 Hhex 

Gene Synonyms/Alias

 Prh; Prhx 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
173	PERKRLAKMLQLSER	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. 

Sequence Annotation

 DNA_BIND 138 197 Homeobox.  

Keyword

 Complete proteome; Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0032993; C:protein-DNA complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0008301; F:DNA binding, bending; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0030183; P:B cell differentiation; IMP:BHF-UCL.
 GO:0007049; P:cell cycle; IEA:Compara.
 GO:0061009; P:common bile duct development; IMP:MGI.
 GO:0071103; P:DNA conformation change; IEA:Compara.
 GO:0035050; P:embryonic heart tube development; IMP:MGI.
 GO:0048568; P:embryonic organ development; IMP:MGI.
 GO:0007492; P:endoderm development; IMP:MGI.
 GO:0048853; P:forebrain morphogenesis; IMP:MGI.
 GO:0061010; P:gall bladder development; IMP:MGI.
 GO:0061011; P:hepatic duct development; IMP:MGI.
 GO:0061017; P:hepatoblast differentiation; IMP:MGI.
 GO:0070365; P:hepatocyte differentiation; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0022027; P:interkinetic nuclear migration; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0002573; P:myeloid leukocyte differentiation; IMP:MGI.
 GO:0016525; P:negative regulation of angiogenesis; IDA:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; IDA:BHF-UCL.
 GO:0031016; P:pancreas development; IMP:MGI.
 GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030177; P:positive regulation of Wnt receptor signaling pathway; IMP:UniProtKB.
 GO:0060431; P:primary lung bud formation; IMP:MGI.
 GO:0090009; P:primitive streak formation; IMP:MGI.
 GO:0034504; P:protein localization to nucleus; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IMP:MGI.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0007165; P:signal transduction; IMP:MGI.
 GO:0030878; P:thyroid gland development; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001570; P:vasculogenesis; IMP:MGI.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS

 PR00024; HOMEOBOX.