CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029523
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 3-kinase catalytic subunit type 3 
Protein Synonyms/Alias
  
Gene Name
 PIK3C3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
33EWLKLPVKYPDLPRNubiquitination[1]
69TTVSLFGKYGMFRQGubiquitination[1]
95ADGSEPTKTPGRTSSubiquitination[1, 2]
146EMINESEKRSSNFMYubiquitination[1]
567FKTEDGGKYPVIFKHubiquitination[3]
643SIQNFFRKYAPSENGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 824 AA 
Protein Sequence
MGEAEKFHYI YSCDLDINVQ LKIWNEWLKL PVKYPDLPRN AQVALTIWDV YGPGKAVPVG 60
GTTVSLFGKY GMFRQGMHDL KVWPNVEADG SEPTKTPGRT SSTLSEDQMS RLAKLTKAHR 120
QGHMVKVDWL DRLTFREIEM INESEKRSSN FMYLMVEFRC VKCDDKEYGI VYYEKDGDES 180
SPILTSFELV KVPDPQMSME NLVESKHHKL ARSLRSGPSD HDLKPNAATR DQLNIIVSYP 240
PTKQLTYEEQ DLVWKFRYYL TNQEKALTKF LKCVNWDLPQ EAKQALELLG KWKPMDVEDS 300
LELLSSHYTN PTVRRYAVAR LRQADDEDLL MYLLQLVQAL KYENFDDIKN GLEPTKKDSQ 360
SSVSENVSNS GINSAEIDSS QIITSPLPSV SSPPPASKTK EVPDGENLEQ DLCTFLISRA 420
CKNSTLANYL YWYVIVECED QDTQQRDPKT HEMYLNVMRR FSQALLKGDK SVRVMRSLLA 480
AQQTFVDRLV HLMKAVQRES GNRKKKNERL QALLGDNEKM NLSDVELIPL PLEPQVKIRG 540
IIPETATLFK SALMPAQLFF KTEDGGKYPV IFKHGDDLRQ DQLILQIISL MDKLLRKENL 600
DLKLTPYKVL ATSTKHGFMQ FIQSVPVAEV LDTEGSIQNF FRKYAPSENG PNGISAEVMD 660
TYVKSCAGYC VITYILGVGD RHLDNLLLTK TGKLFHIDFG YILGRDPKPL PPPMKLNKEM 720
VEGMGGTQSE QYQEFRKQCY TAFLHLRRYS NLILNLFSLM VDANIPDIAL EPDKTVKKVQ 780
DKFRLDLSDE EAVHYMQSLI DESVHALFAA VVEQIHKFAQ YWRK 824 
Gene Ontology
 GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IEA:GOC.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR002420; PI3K_C2_dom.
 IPR008290; PI3K_Vps34.
 IPR015433; PI_Kinase.
 IPR001263; PInositide-3_kin_accessory_dom. 
Pfam
 PF00454; PI3_PI4_kinase
 PF00792; PI3K_C2
 PF00613; PI3Ka 
SMART
 SM00145; PI3Ka
 SM00146; PI3Kc 
PROSITE
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3
 PS51547; PI3K_C2
 PS51545; PIK_HELICAL 
PRINTS