CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010937
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial 
Protein Synonyms/Alias
 MMSDH; Malonate-semialdehyde dehydrogenase [acylating]; Aldehyde dehydrogenase family 6 member A1 
Gene Name
 ALDH6A1 
Gene Synonyms/Alias
 MMSDH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52GGKFVESKSDKWIDIacetylation[1]
55FVESKSDKWIDIHNPacetylation[1]
364PLITPQAKERVCNLIubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. 
Sequence Annotation
 NP_BIND 209 213 NAD (Potential).
 NP_BIND 261 266 NAD (Potential).
 ACT_SITE 317 317 Nucleophile (By similarity).
 BINDING 417 417 NAD (Potential).
 MOD_RES 55 55 N6-acetyllysine (By similarity).
 MOD_RES 117 117 N6-acetyllysine (By similarity).
 MOD_RES 331 331 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Disease mutation; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 535 AA 
Protein Sequence
MAALLAAAAV RARILQVSSK VKSSPTWYSA SSFSSSVPTV KLFIGGKFVE SKSDKWIDIH 60
NPATNEVIGR VPQATKAEMD AAIASCKRAF PAWADTSVLS RQQVLLRYQQ LIKENLKEIA 120
KLITLEQGKT LADAEGDVFR GLQVVEHACS VTSLMMGETM PSITKDMDLY SYRLPLGVCA 180
GIAPFNFPAM IPLWMFPMAM VCGNTFLMKP SERVPGATML LAKLLQDSGA PDGTLNIIHG 240
QHEAVNFICD HPDIKAISFV GSNKAGEYIF ERGSRHGKRV QANMGAKNHG VVMPDANKEN 300
TLNQLVGAAF GAAGQRCMAL STAVLVGEAK KWLPELVEHA KNLRVNAGDQ PGADLGPLIT 360
PQAKERVCNL IDSGTKEGAS ILLDGRKIKV KGYENGNFVG PTIISNVKPN MTCYKEEIFG 420
PVLVVLETET LDEAIQIVNN NPYGNGTAIF TTNGATARKY AHLVDVGQVG VNVPIPVPLP 480
MFSFTGSRSS FRGDTNFYGK QGIQFYTQLK TITSQWKEED ATLSSPAVVM PTMGR 535 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0000062; F:fatty-acyl-CoA binding; ISS:UniProtKB.
 GO:0018478; F:malonate-semialdehyde dehydrogenase (acetylating) activity; ISS:UniProtKB.
 GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating) activity; ISS:UniProtKB.
 GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara.
 GO:0019859; P:thymine metabolic process; ISS:UniProtKB.
 GO:0006573; P:valine metabolic process; ISS:UniProtKB. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010061; MeMal-semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS