UniProt Accession

 SODE_MOUSE; O09164 

Genbank Protein ID

 U38261; D50856; AF223251 

Genbank Nucleotide ID

 AAB51106.1; BAA23493.1; AAF27932.1 

Protein Name

 Extracellular superoxide dismutase [Cu-Zn] 

Protein Synonyms/Alias

 EC-SOD 

Gene Name

 Sod3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
203	AGEDDLGKGGNQASL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen (By similarity). 

Sequence Annotation

 METAL 128 128 Copper; catalytic (By similarity).
 METAL 130 130 Copper; catalytic (By similarity).
 METAL 145 145 Copper; catalytic (By similarity).
 METAL 145 145 Zinc; structural (By similarity).
 METAL 153 153 Zinc; structural (By similarity).
 METAL 156 156 Zinc; structural (By similarity).
 METAL 159 159 Zinc; structural (By similarity).
 METAL 195 195 Copper; catalytic (By similarity).
 CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
 DISULFID 77 222 By similarity.
 DISULFID 139 221 By similarity.  

Keyword

 3D-structure; Antioxidant; Complete proteome; Copper; Direct protein sequencing; Disulfide bond; Glycoprotein; Metal-binding; Oxidoreductase; Reference proteome; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0005739; C:mitochondrion; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0005802; C:trans-Golgi network; IDA:MGI.
 GO:0005507; F:copper ion binding; IBA:RefGenome.
 GO:0004784; F:superoxide dismutase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IBA:RefGenome.
 GO:0019430; P:removal of superoxide radicals; IBA:RefGenome.
 GO:0046688; P:response to copper ion; IEA:Compara.
 GO:0001666; P:response to hypoxia; IMP:MGI. 

Interpro

 IPR024134; SOD_Cu/Zn_/chaperones.
 IPR018152; SOD_Cu/Zn_BS.
 IPR024141; SOD_Cu/Zn_extracel.
 IPR001424; SOD_Cu_Zn_dom. 

Pfam

 PF00080; Sod_Cu 

SMART

  

PROSITE

 PS00087; SOD_CU_ZN_1
 PS00332; SOD_CU_ZN_2 

PRINTS

 PR00068; CUZNDISMTASE.