UniProt Accession

 RBM45_HUMAN; Q8IUH3; Q6NYL0; Q8NFC9 

Genbank Protein ID

 AB036991; AF526533; BC066549 

Genbank Nucleotide ID

 BAC16207.1; AAM88417.1; AAH66549.1 

Protein Name

 RNA-binding protein 45 

Protein Synonyms/Alias

 Developmentally-regulated RNA-binding protein 1; RB-1; RNA-binding motif protein 45 

Gene Name

 RBM45 

Gene Synonyms/Alias

 DRB1; DRBP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
235	SEFSSFDKNDSRGQE	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. 

Sequence Annotation

 DOMAIN 26 106 RRM 1.
 DOMAIN 121 195 RRM 2.
 DOMAIN 392 464 RRM 3.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Neurogenesis; Nucleus; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 476 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; ISS:UniProtKB. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS