CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024632
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycerol kinase 
Protein Synonyms/Alias
 ATP:glycerol 3-phosphotransferase; Glycerokinase; GK 
Gene Name
 glpK 
Gene Synonyms/Alias
 ECDH10B_4115 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12 / DH10B) 
NCBI Taxa ID
 316385 
Lysine Modification
Position
Peptide
Type
References
233GQTNIGGKGGTRIPImalonylation[1]
Reference
 [1] The first identification of lysine malonylation substrates and its regulatory enzyme.
 Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y.
 Mol Cell Proteomics. 2011 Dec;10(12):M111.012658. [PMID: 21908771] 
Functional Description
 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). 
Sequence Annotation
 NP_BIND 412 416 ATP (By similarity).
 BINDING 14 14 Substrate (By similarity).
 BINDING 18 18 ATP (By similarity).
 BINDING 84 84 Substrate (By similarity).
 BINDING 136 136 Substrate (By similarity).
 BINDING 246 246 Substrate (By similarity).
 BINDING 268 268 ATP (By similarity).
 BINDING 311 311 ATP; via carbonyl oxygen (By similarity).  
Keyword
 ATP-binding; Complete proteome; Glycerol metabolism; Kinase; Nucleotide-binding; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 502 AA 
Protein Sequence
MTEKKYIVAL DQGTTSSRAV VMDHDANIIS VSQREFEQIY PKPGWVEHDP MEIWATQSST 60
LVEVLAKADI SSDQIAAIGI TNQRETTIVW EKETGKPIYN AIVWQCRRTA EICEHLKRDG 120
LEDYIRSNTG LVIDPYFSGT KVKWILDHVE GSRERARRGE LLFGTVDTWL IWKMTQGRVH 180
VTDYTNASRT MLFNIHTLDW DDKMLEVLDI PREMLPEVRR SSEVYGQTNI GGKGGTRIPI 240
SGIAGDQQAA LFGQLCVKEG MAKNTYGTGC FMLMNTGEKA VKSENGLLTT IACGPTGEVN 300
YALEGAVFMA GASIQWLRDE MKLINDAYDS EYFATKVQNT NGVYVVPAFT GLGAPYWDPY 360
ARGAIFGLTR GVNANHIIRA TLESIAYQTR DVLEAMQADS GIRLHALRVD GGAVANNFLM 420
QFQSDILGTR VERPEVREVT ALGAAYLAGL AVGFWQNLDE LQEKAVIERE FRPGIETTER 480
NYRYAGWKKA VKRAMAWEEH DE 502 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
 GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP. 
Interpro
 IPR018485; Carb_kinase_FGGY_C.
 IPR018483; Carb_kinase_FGGY_CS.
 IPR018484; Carb_kinase_FGGY_N.
 IPR005999; Glycerol_kin. 
Pfam
 PF02782; FGGY_C
 PF00370; FGGY_N 
SMART
  
PROSITE
 PS00933; FGGY_KINASES_1
 PS00445; FGGY_KINASES_2 
PRINTS