| Tag | Content |
|---|
| CPLM ID | CPLM-013830 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | WD repeat-containing protein 6 |
Protein Synonyms/Alias | |
Gene Name | WDR6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
NCBI Taxa ID | 9601 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 237 | DRSVRIWKVGDLRVP | ubiquitination | [1] | | 343 | GVSALCFKSRSRPGT | ubiquitination | [1] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Enhances the STK11/LKB1-induced cell growth suppression activity (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity). |
Sequence Annotation | REPEAT 89 130 WD 1.
REPEAT 155 197 WD 2.
REPEAT 207 246 WD 3.
REPEAT 256 294 WD 4.
REPEAT 295 335 WD 5.
REPEAT 346 384 WD 6.
REPEAT 433 475 WD 7.
REPEAT 489 528 WD 8.
REPEAT 567 605 WD 9.
REPEAT 611 650 WD 10.
REPEAT 652 692 WD 11.
REPEAT 747 793 WD 12.
REPEAT 857 901 WD 13.
REPEAT 908 954 WD 14.
REPEAT 978 1020 WD 15.
REPEAT 1043 1081 WD 16. |
Keyword | Cell cycle; Complete proteome; Cytoplasm; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1121 AA |
Protein Sequence | MDALEDYVWP RATSELILLP VTGLECVGDR LLAGEGPDVL VYSLDFGGHL RMIKRVQNLL 60
GHYLIHGFRI RPEPNGDLDL EAMVAVFGSK GLRVVKISWG QGHFRELWRS GLWNMSDWIW 120
DARWLEGNIA LALGHNSVVL YDPVVGCILQ EVPCTDRCTL SSACLIGDAW KELTIVAGAV 180
SNQLLVWYPA TALADNKPVA PDRRISGHVG IIFSMSYLES KGLLATASED RSVRIWKVGD 240
LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG 300
IRAIAAHERQ AWVITGGDDS GIRLWHLVGR GYRGLGVSAL CFKSRSRPGT LKAVTLAGSW 360
RLLAVTDTGA LYLYDVEVKR WEQLLEDKHF QSYCLLEAAP GPEGFGLCAM ANGEGRVKVV 420
PINTPTAAVD RTLFPGKVHS LSWALRGYEE LLLLASGPGG VVACLEISAA PSGKAIFVKE 480
RCRYLLPPSK QRWHTCSAFL PPGDFLVCSD RRGSVLLFPS RPGLLKDPGV GGKAGAGAGA 540
PGVGSGSSGG GNAFTGLGPV STLPSLHGKQ GVTSVTCHGG YVYTTGRDGA YYQLFVRDSQ 600
LQPVLRQKSC RGMNWLAGLR IVPDGSMVIL GFHANEFVVW NPRSHEKLHI VNCGGGHRSW 660
AFSDTEAAMA FAYLKDGDVM LYRALGGCTR PHVILREGLH GREITCVKRV GTITLGPEYG 720
VPSFMQPDDL EPGSEGPDLT DIVITCSEDT TVCVLALPTT TGSAHALTAV CNHISSVRAV 780
AVWGIGTPGG PQDPQPGLSA HVVSAGGRAE MHCFSIMVTP DPSTPSRLAC HVMHLSSHRL 840
DEYWDRQHNR HRMVKVDPET RYMSLAVCEL DQPSLGPLVA AACSDGAVRL FLLQDSGRIL 900
QLLAETFHHK RCVLKVHSFT HEVPNQRRRL LLCSAATDGS LAFWDLTTML DHDSTVLEPP 960
VDPGLPYRLG TPSLTLQAHS CGINSLHTLP TREGHHLVAS GSEDGSLHVF VLAVEMLELE 1020
EAVGEAGLVP QLRVLEEYSV PCAHAAHVTG LKILSPSIMV SASIDQRLTF WRLGHGEPTF 1080
MNSTVFHVPD VADMDCWPVS PEFGHRCALG GQGLEVYNWY D 1121 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |