CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022232
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trimeric intracellular cation channel type B 
Protein Synonyms/Alias
 TRIC-B; TRICB; Transmembrane protein 38B 
Gene Name
 TMEM38B 
Gene Synonyms/Alias
 C9orf87 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
166TNFERLVKGDWKPEGubiquitination[1, 2, 3, 4]
170RLVKGDWKPEGDEWLubiquitination[2, 3]
273GVGSLASKPVDVASDubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). 
Sequence Annotation
 MOD_RES 262 262 Phosphoserine.  
Keyword
 Complete proteome; Endoplasmic reticulum; Ion channel; Ion transport; Membrane; Osteogenesis imperfecta; Phosphoprotein; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 291 AA 
Protein Sequence
MDSPWDELAL AFSRTSMFPF FDIAHYLVSV MAVKRQPGAA ALAWKNPISS WFTAMLHCFG 60
GGILSCLLLA EPPLKFLANH TNILLASSIW YITFFCPHDL VSQGYSYLPV QLLASGMKEV 120
TRTWKIVGGV THANSYYKNG WIVMIAIGWA RGAGGTIITN FERLVKGDWK PEGDEWLKMS 180
YPAKVTLLGS VIFTFQHTQH LAISKHNLMF LYTIFIVATK ITMMTTQTST MTFAPFEDTL 240
SWMLFGWQQP FSSCEKKSEA KSPSNGVGSL ASKPVDVASD NVKKKHTKKN E 291 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031965; C:nuclear membrane; NAS:BHF-UCL.
 GO:0033017; C:sarcoplasmic reticulum membrane; NAS:BHF-UCL.
 GO:0005267; F:potassium channel activity; TAS:BHF-UCL. 
Interpro
 IPR007866; TRIC_channel. 
Pfam
 PF05197; TRIC 
SMART
  
PROSITE
  
PRINTS