CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022878
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 
Protein Synonyms/Alias
 MALT lymphoma-associated translocation; Paracaspase 
Gene Name
 MALT1 
Gene Synonyms/Alias
 MLT 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
648IDPKDANKGTPEETGubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. 
Sequence Annotation
 DOMAIN 39 126 Death.
 DOMAIN 125 201 Ig-like C2-type 1.
 DOMAIN 212 305 Ig-like C2-type 2.
 REGION 348 562 Caspase-like.
 MOTIF 369 376 Nuclear export signal.
 ACT_SITE 415 415 By similarity.
 ACT_SITE 464 464 By similarity.
 MOD_RES 135 135 Phosphoserine.
 DISULFID 147 190 Potential.
 DISULFID 248 290 Potential.  
Keyword
 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Disulfide bond; Hydrolase; Immunoglobulin domain; Nucleus; Phosphoprotein; Polymorphism; Protease; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 824 AA 
Protein Sequence
MSLLGDPLQA LPPSAAPTGP LLAPPAGATL NRLREPLLRR LSELLDQAPE GRGWRRLAEL 60
AGSRGRLRLS CLDLEQCSLK VLEPEGSPSL CLLKLMGEKG CTVTELSDFL QAMEHTEVLQ 120
LLSPPGIKIT VNPESKAVLA GQFVKLCCRA TGHPFVQYQW FKMNKEIPNG NTSELIFNAV 180
HVKDAGFYVC RVNNNFTFEF SQWSQLDVCD IPESFQRSVD GVSESKLQIC VEPTSQKLMP 240
GSTLVLQCVA VGSPIPHYQW FKNELPLTHE TKKLYMVPYV DLEHQGTYWC HVYNDRDSQD 300
SKKVEIIIGR TDEAVECTED ELNNLGHPDN KEQTTDQPLA KDKVALLIGN MNYREHPKLK 360
APLVDVYELT NLLRQLDFKV VSLLDLTEYE MRNAVDEFLL LLDKGVYGLL YYAGHGYENF 420
GNSFMVPVDA PNPYRSENCL CVQNILKLMQ EKETGLNVFL LDMCRKRNDY DDTIPILDAL 480
KVTANIVFGY ATCQGAEAFE IQHSGLANGI FMKFLKDRLL EDKKITVLLD EVAEDMGKCH 540
LTKGKQALEI RSSLSEKRAL TDPIQGTEYS AESLVRNLQW AKAHELPESM CLKFDCGVQI 600
QLGFAAEFSN VMIIYTSIVY KPPEIIMCDA YVTDFPLDLD IDPKDANKGT PEETGSYLVS 660
KDLPKHCLYT RLSSLQKLKE HLVFTVCLSY QYSGLEDTVE DKQEVNVGKP LIAKLDMHRG 720
LGRKTCFQTC LMSNGPYQSS AATSGGAGHY HSLQDPFHGV YHSHPGNPSN VTPADSCHCS 780
RTPDAFISSF AHHASCHFSR SNVPVETTDE IPFSFSDRLR ISEK 824 
Gene Ontology
 GO:0032449; C:CBM complex; NAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0004197; F:cysteine-type endopeptidase activity; NAS:UniProtKB.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
 GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IMP:UniProtKB.
 GO:0001923; P:B-1 B cell differentiation; IEA:Compara.
 GO:0006952; P:defense response; NAS:UniProtKB.
 GO:0045087; P:innate immune response; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; NAS:UniProtKB.
 GO:0051168; P:nuclear export; IDA:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
 GO:0032743; P:positive regulation of interleukin-2 production; IMP:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.
 GO:0031398; P:positive regulation of protein ubiquitination; NAS:BHF-UCL.
 GO:0050870; P:positive regulation of T cell activation; IC:UniProtKB.
 GO:0002726; P:positive regulation of T cell cytokine production; IMP:UniProtKB.
 GO:0051259; P:protein oligomerization; IDA:UniProtKB.
 GO:0006508; P:proteolysis; IDA:BHF-UCL.
 GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:Compara.
 GO:0009620; P:response to fungus; IEA:Compara.
 GO:0002237; P:response to molecule of bacterial origin; IEA:Compara.
 GO:0042098; P:T cell proliferation; IEA:Compara.
 GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011600; Pept_C14_cat.
 IPR001309; Pept_C14_ICE_p20. 
Pfam
 PF00656; Peptidase_C14 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50208; CASPASE_P20
 PS50017; DEATH_DOMAIN
 PS50835; IG_LIKE 
PRINTS