UniProt Accession

 RHO5_YEAST; P53879; D6W106 

Genbank Protein ID

 Z71456; BK006947 

Genbank Nucleotide ID

 CAA96072.1; DAA10372.1 

Protein Name

 GTP-binding protein RHO5 

Protein Synonyms/Alias

  

Gene Name

 RHO5 

Gene Synonyms/Alias

 YNL180C; N1644 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
169	DDPATQKKLQEANSD	ubiquitination	[1]
227	EPESPNQKSANHTLT	ubiquitination	[1]
248	TTNTNGDKNIREQKQ	ubiquitination	[1]
276	KGSLQQEKEALNIKP	ubiquitination	[1, 2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Negatively regulates a MAP kinase branch, downstream of SLT2, of the PKC1-mediated signal transduction pathway. 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 87 91 GTP (By similarity).
 NP_BIND 156 159 GTP (By similarity).
 MOD_RES 223 223 Phosphoserine.
 MOD_RES 228 228 Phosphoserine.
 MOD_RES 232 232 Phosphothreonine.
 MOD_RES 244 244 Phosphothreonine.
 MOD_RES 328 328 Cysteine methyl ester (By similarity).
 LIPID 328 328 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0012505; C:endomembrane system; IDA:SGD.
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0007266; P:Rho protein signal transduction; ISS:SGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.